Title |
Effects of Microcystis on Hypothalamic-Pituitary-Gonadal-Liver Axis in Nile Tilapia (Oreochromis niloticus)
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Published in |
Bulletin of Environmental Contamination and Toxicology, February 2017
|
DOI | 10.1007/s00128-017-2051-4 |
Pubmed ID | |
Authors |
Jiazhang Chen, Shunlong Meng, Hai Xu, Zhen Zhang, Xiangyang Wu |
Abstract |
In the present study, Nile tilapia (Oreochromis niloticus) were used to assess the endocrine disruption potential of Microcytis aeruginosa. Male Nile tilapia were exposed to lyophilized M. aeruginosa or purified microcystin-LR (8.3 μg/L) for 28 days. The levels of serum hormones (17β-estradiol and testosterone) and transcripts of selected genes in the hypothalamus-pituitary-gonadal-liver axis were analyzed. The results showed that serum hormones were significantly up-regulated, and transcripts of 13 genes (GHRH, PACAP, GH, GHR1, GHR2, IGF1, IGF2, CYP19a, CYP19b, 3β-HSD1, 20β-HSD, 17β-HSD1 and 17β-HSD8) were significantly altered after Microcytis exposure. These results indicate that fish reproduction can be altered in a Microcystis bloom-contaminated aquatic environment. |
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Unknown | 2 | 100% |
Demographic breakdown
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Members of the public | 2 | 100% |
Mendeley readers
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United Kingdom | 1 | 5% |
Unknown | 20 | 95% |
Demographic breakdown
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Student > Ph. D. Student | 5 | 24% |
Researcher | 3 | 14% |
Lecturer | 2 | 10% |
Professor > Associate Professor | 2 | 10% |
Student > Master | 2 | 10% |
Other | 2 | 10% |
Unknown | 5 | 24% |
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Chemistry | 2 | 10% |
Other | 3 | 14% |
Unknown | 7 | 33% |