| Title |
Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects
|
|---|---|
| Published in |
European Journal of Nutrition, February 2017
|
| DOI | 10.1007/s00394-016-1376-9 |
| Pubmed ID | |
| Authors |
Martin Purpura, Ryan P. Lowery, Jacob M. Wilson, Haider Mannan, Gerald Münch, Valentina Razmovski-Naumovski |
| Abstract |
The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorption. In this study, we investigated the bioavailability of a new γ-cyclodextrin curcumin formulation (CW8). This formulation was compared to a standardized unformulated curcumin extract (StdC) and two commercially available formulations with purported increased bioavailability: a curcumin phytosome formulation (CSL) and a formulation of curcumin with essential oils of turmeric extracted from the rhizome (CEO). Twelve healthy human volunteers participated in a double-blinded, cross-over study. The plasma concentrations of the individual curcuminoids that are present in turmeric (namely curcumin, demethoxycurcumin, and bisdemethoxycurcumin) were determined at baseline and at various intervals after oral administration over a 12-h period. CW8 showed the highest plasma concentrations of curcumin, demethoxycurcumin, and total curcuminoids, whereas CSL administration resulted in the highest levels of bisdemethoxycurcumin. CW8 (39-fold) showed significantly increased relative bioavailability of total curcuminoids (AUC0-12) in comparison with the unformulated StdC. The data presented suggest that γ-cyclodextrin curcumin formulation (CW8) significantly improves the absorption of curcuminoids in healthy humans. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Switzerland | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Practitioners (doctors, other healthcare professionals) | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 268 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 268 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 51 | 19% |
| Student > Bachelor | 34 | 13% |
| Researcher | 25 | 9% |
| Student > Doctoral Student | 16 | 6% |
| Student > Ph. D. Student | 15 | 6% |
| Other | 45 | 17% |
| Unknown | 82 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 33 | 12% |
| Medicine and Dentistry | 31 | 12% |
| Biochemistry, Genetics and Molecular Biology | 28 | 10% |
| Agricultural and Biological Sciences | 21 | 8% |
| Chemistry | 13 | 5% |
| Other | 45 | 17% |
| Unknown | 97 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 42. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2023.
All research outputs
#943,658
of 24,654,416 outputs
Outputs from European Journal of Nutrition
#258
of 2,538 outputs
Outputs of similar age
#19,415
of 311,549 outputs
Outputs of similar age from European Journal of Nutrition
#5
of 46 outputs
Altmetric has tracked 24,654,416 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,538 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one has done well, scoring higher than 89% of its peers.
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We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.