Title |
Waspergillamide A, a Nitro depsi-Tetrapeptide Diketopiperazine from an Australian Mud Dauber Wasp-Associated Aspergillus sp. (CMB-W031)
|
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Published in |
Journal of Natural Products, February 2017
|
DOI | 10.1021/acs.jnatprod.6b01062 |
Pubmed ID | |
Authors |
Michelle Quezada, Zhuo Shang, Pabasara Kalansuriya, Angela A. Salim, Ernest Lacey, Robert J. Capon |
Abstract |
Chemical profiling of extracts from a mud dauber wasp-associated fungus, Aspergillus sp. (CMB-W031), revealed a remarkably diverse array of secondary metabolites, with many biosynthetic gene clusters being transcriptionally responsive to specific culture conditions. Chemical fractionation of a jasmine rice cultivation yielded many known fungal metabolites, including the highly cytotoxic (-)-stephacidin B and an unprecedented nonribosomal peptide synthase derived nitro depsi-tetrapeptide diketopiperazine, waspergillamide A (1). All structures were assigned by detailed spectroscopic analysis and, where appropriate, chemical degradation and Marfey's analysis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 3 | 23% |
Researcher | 2 | 15% |
Student > Ph. D. Student | 2 | 15% |
Student > Doctoral Student | 1 | 8% |
Lecturer > Senior Lecturer | 1 | 8% |
Other | 0 | 0% |
Unknown | 4 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 4 | 31% |
Biochemistry, Genetics and Molecular Biology | 3 | 23% |
Business, Management and Accounting | 1 | 8% |
Medicine and Dentistry | 1 | 8% |
Unknown | 4 | 31% |