| Title |
The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, September 2006
|
| DOI | 10.1007/s00018-006-6192-6 |
| Pubmed ID | |
| Authors |
X. -B. Qiu, Y. -M. Shao, S. Miao, L. Wang |
| Abstract |
DnaJ/Hsp40 (heat shock protein 40) proteins have been preserved throughout evolution and are important for protein translation, folding, unfolding, translocation, and degradation, primarily by stimulating the ATPase activity of chaperone proteins, Hsp70s. Because the ATP hydrolysis is essential for the activity of Hsp70s, DnaJ/Hsp40 proteins actually determine the activity of Hsp70s by stabilizing their interaction with substrate proteins. DnaJ/Hsp40 proteins all contain the J domain through which they bind to Hsp70s and can be categorized into three groups, depending on the presence of other domains. Six DnaJ homologs have been identified in Escherichia coli and 22 in Saccharomyces cerevisiae. Genome-wide analysis has revealed 41 DnaJ/Hsp40 family members (or putative members) in humans. While 34 contain the typical J domains, 7 bear partially conserved J-like domains, but are still suggested to function as DnaJ/ Hsp40 proteins. DnaJA2b, DnaJB1b, DnaJC2, DnaJC20, and DnaJC21 are named for the first time in this review; all other human DnaJ proteins were dubbed according to their gene names, e.g. DnaJA1 is the human protein named after its gene DNAJA1. This review highlights the progress in studying the domains in DnaJ/Hsp40 proteins, introduces the mechanisms by which they interact with Hsp70s, and stresses their functional diversity. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 603 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| France | 2 | <1% |
| United Kingdom | 2 | <1% |
| Germany | 1 | <1% |
| Colombia | 1 | <1% |
| Sweden | 1 | <1% |
| Brazil | 1 | <1% |
| Australia | 1 | <1% |
| Mexico | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 587 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 151 | 25% |
| Researcher | 92 | 15% |
| Student > Master | 79 | 13% |
| Student > Bachelor | 69 | 11% |
| Student > Doctoral Student | 28 | 5% |
| Other | 70 | 12% |
| Unknown | 114 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 188 | 31% |
| Biochemistry, Genetics and Molecular Biology | 177 | 29% |
| Medicine and Dentistry | 25 | 4% |
| Chemistry | 22 | 4% |
| Neuroscience | 18 | 3% |
| Other | 48 | 8% |
| Unknown | 125 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2024.
All research outputs
#1,478,176
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#140
of 4,151 outputs
Outputs of similar age
#2,540
of 68,234 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#2
of 29 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.