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Mendeley readers
Attention Score in Context
| Title |
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
|
|---|---|
| Published in |
Nature, August 1988
|
| DOI | 10.1038/334676a0 |
| Pubmed ID | |
| Authors |
Christopher C. Goodnow, Jeffrey Crosbie, Stephen Adelstein, Thomas B. Lavoie, Sandra J. Smith-Gill, Robert A. Brink, Helen Pritchard-Briscoe, John S. Wotherspoon, Robert H. Loblay, Kathy Raphael, Ronald J. Trent, Antony Basten |
| Abstract |
Immunological tolerance has been demonstrated in double-transgenic mice expressing the genes for a neo-self antigen, hen egg lysozyme, and a high affinity anti-lysozyme antibody. The majority of anti-lysozyme B-cells did not undergo clonal deletion, but were no longer able to secrete anti-lysozyme antibody and displayed markedly reduced levels of surface IgM while continuing to express high levels of surface IgD. These findings indicate that self tolerance may result from mechanisms other than clonal deletion, and are consistent with the hypothesis that IgD may have a unique role in B-cell tolerance. |
Mendeley readers
The data shown below were compiled from readership statistics for 350 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | <1% |
| United States | 3 | <1% |
| United Kingdom | 2 | <1% |
| Switzerland | 1 | <1% |
| Canada | 1 | <1% |
| Brazil | 1 | <1% |
| Denmark | 1 | <1% |
| Singapore | 1 | <1% |
| Unknown | 337 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 92 | 26% |
| Researcher | 57 | 16% |
| Student > Master | 33 | 9% |
| Student > Bachelor | 33 | 9% |
| Student > Doctoral Student | 21 | 6% |
| Other | 64 | 18% |
| Unknown | 50 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 101 | 29% |
| Immunology and Microbiology | 77 | 22% |
| Medicine and Dentistry | 47 | 13% |
| Biochemistry, Genetics and Molecular Biology | 45 | 13% |
| Neuroscience | 4 | 1% |
| Other | 22 | 6% |
| Unknown | 54 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2024.
All research outputs
#1,951,081
of 23,367,368 outputs
Outputs from Nature
#40,899
of 92,168 outputs
Outputs of similar age
#280
of 13,233 outputs
Outputs of similar age from Nature
#13
of 189 outputs
Altmetric has tracked 23,367,368 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 92,168 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 100.2. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 13,233 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 189 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.