| Title |
A disulfide linked model of the complement protein C8γ complexed with C8α indel peptide
|
|---|---|
| Published in |
Journal of Molecular Modeling, December 2008
|
| DOI | 10.1007/s00894-008-0412-y |
| Pubmed ID | |
| Authors |
Athanassios Stavrakoudis |
| Abstract |
In a recent study C8gamma (complement protein) with Cys40Ala substitution and a C8alpha derived peptide with Cys164Ala substitution were co-crystallized and their binding mode was revealed. Computer modeling and molecular dynamics simulations were performed in order to check the hypothesis that the residues Ala164 of C8alpha and Ala40 of C8gamma occupied the right position if cysteine residues were in their place for disulfide bonding. Substitution of these two alanine residues with cysteine along with disulfide bond creation via molecular modeling and subsequent molecular dynamics simulation of the complex corroborated the hypothesis, which was also confirmed from recent crystallographic data. Average RMSD between backbone atoms of the indel peptide during the MD trajectory in comparison with the corresponding sequence of crystal structure of the C8alpha/gamma complex was found only 0.085 nm. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Greece | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 38% |
| Student > Bachelor | 2 | 25% |
| Student > Ph. D. Student | 1 | 13% |
| Student > Postgraduate | 1 | 13% |
| Unknown | 1 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 2 | 25% |
| Agricultural and Biological Sciences | 2 | 25% |
| Business, Management and Accounting | 1 | 13% |
| Chemistry | 1 | 13% |
| Unknown | 2 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2013.
All research outputs
#15,276,424
of 22,716,996 outputs
Outputs from Journal of Molecular Modeling
#408
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Outputs of similar age
#139,009
of 165,996 outputs
Outputs of similar age from Journal of Molecular Modeling
#16
of 18 outputs
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