| Title |
Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons
|
|---|---|
| Published in |
Molecular Neurobiology, February 2017
|
| DOI | 10.1007/s12035-017-0451-4 |
| Pubmed ID | |
| Authors |
Laura Urrea, Miriam Segura-Feliu, Masami Masuda-Suzukake, Arnau Hervera, Lucas Pedraz, José Manuel García Aznar, Miquel Vila, Josep Samitier, Eduard Torrents, Isidro Ferrer, Rosalina Gavín, Masato Hagesawa, José Antonio del Río |
| Abstract |
The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of β-amyloid. Their interaction is mandatory for neurotoxic effects of β-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of α-synuclein. Results demonstrate that Prnp expression is not mandatory for α-synuclein spreading. However, although the pathological spreading of α-synuclein can take place in the absence of Prnp, α-synuclein expanded faster in PrP(C)-overexpressing mice. In addition, α-synuclein binds strongly on PrP(C)-expressing cells, suggesting a role in modulating the effect of α-synuclein fibrils. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 4 | 67% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| Unknown | 85 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 35% |
| Student > Bachelor | 11 | 13% |
| Researcher | 8 | 9% |
| Student > Doctoral Student | 4 | 5% |
| Student > Master | 4 | 5% |
| Other | 10 | 12% |
| Unknown | 19 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 22 | 26% |
| Neuroscience | 18 | 21% |
| Agricultural and Biological Sciences | 15 | 17% |
| Medicine and Dentistry | 5 | 6% |
| Immunology and Microbiology | 3 | 3% |
| Other | 3 | 3% |
| Unknown | 20 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 June 2021.
All research outputs
#1,852,476
of 25,619,480 outputs
Outputs from Molecular Neurobiology
#154
of 3,998 outputs
Outputs of similar age
#35,123
of 324,967 outputs
Outputs of similar age from Molecular Neurobiology
#3
of 80 outputs
Altmetric has tracked 25,619,480 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,998 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done particularly well, scoring higher than 96% of its peers.
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We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.