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Cigarette Smoke Decreases Pulmonary Dendritic Cells and Impacts Antiviral Immune Responsiveness

Overview of attention for article published in American Journal of Respiratory Cell and Molecular Biology, August 2003
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

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Title
Cigarette Smoke Decreases Pulmonary Dendritic Cells and Impacts Antiviral Immune Responsiveness
Published in
American Journal of Respiratory Cell and Molecular Biology, August 2003
DOI 10.1165/rcmb.2003-0259oc
Pubmed ID
Authors

Clinton S. Robbins, David E. Dawe, Susanna I. Goncharova, Mahmoud A. Pouladi, Anna G. Drannik, Filip K. Swirski, Gerard Cox, Martin R. Stämpfli

Abstract

We investigated the impact of cigarette smoke exposure on respiratory immune defense mechanisms. Mice were exposed to two cigarettes daily, 5 d/wk, for 2-4 mo. Tobacco smoke decreased the number of dendritic cells (DCs) in the lung tissue. Furthermore, smoke exposure dramatically reduced the percentage of B7.1-expressing DCs. Because DCs are believed to be indispensable to the initiation of adaptive immune responses, we investigated the impact of cigarette smoke on immune responsiveness toward adenovirus. Mice were exposed to two cigarettes for 2-4 mo and inoculated with 2 x 10(8) pfu of a replication-deficient adenovirus on three occasions, 2 wk apart, during the last month of tobacco smoke exposure. Smoke exposure specifically prevented the expansion and maximal activation of CD4 T cells and reduced the number of both activated CD4 and CD8 T cells. Consequently, smoke exposure shifted the activated CD4:CD8 T cell ratio from 3 to 1.5 when compared with sham exposure. Significant decreases were also observed in serum adenovirus-specific pan IgG, IgG1, and IgG2a immunoglobulin levels, which was associated with diminished viral neutralization capacity. We demonstrate that chronic tobacco smoke exposure impairs the immune response against adenovirus. This may, in part, explain the increased prevalence of viral infections in chronic obstructive pulmonary disease.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 3%
Japan 1 2%
United States 1 2%
Ireland 1 2%
Unknown 57 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 24%
Student > Master 10 16%
Student > Ph. D. Student 9 15%
Student > Bachelor 7 11%
Professor 6 10%
Other 10 16%
Unknown 5 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 23%
Medicine and Dentistry 11 18%
Biochemistry, Genetics and Molecular Biology 8 13%
Immunology and Microbiology 7 11%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 8 13%
Unknown 11 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2014.
All research outputs
#5,240,151
of 25,373,627 outputs
Outputs from American Journal of Respiratory Cell and Molecular Biology
#450
of 3,591 outputs
Outputs of similar age
#9,287
of 53,363 outputs
Outputs of similar age from American Journal of Respiratory Cell and Molecular Biology
#3
of 21 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,591 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 53,363 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.