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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Ascending monoaminergic systems alterations in Alzheimer's disease. Translating basic science into clinical care
|
|---|---|
| Published in |
Neuroscience & Biobehavioral Reviews, May 2013
|
| DOI | 10.1016/j.neubiorev.2013.05.008 |
| Pubmed ID | |
| Authors |
Ludwig Trillo, Devsmita Das, Wayne Hsieh, Brian Medina, Sarah Moghadam, Bill Lin, Van Dang, Martha Millan Sanchez, Zurine De Miguel, J. Wesson Ashford, Ahmad Salehi |
| Abstract |
Extensive neuropathological studies have established a compelling link between abnormalities in structure and function of subcortical monoaminergic (MA-ergic) systems and the pathophysiology of Alzheimer's disease (AD). The main cell populations of these systems including the locus coeruleus, the raphe nuclei, and the tuberomamillary nucleus undergo significant degeneration in AD, thereby depriving the hippocampal and cortical neurons from their critical modulatory influence. These studies have been complemented by genome wide association studies linking polymorphisms in key genes involved in the MA-ergic systems and particular behavioral abnormalities in AD. Importantly, several recent studies have shown that improvement of the MA-ergic systems can both restore cognitive function and reduce AD-related pathology in animal models of neurodegeneration. This review aims to explore the link between abnormalities in the MA-ergic systems and AD symptomatology as well as the therapeutic strategies targeting these systems. Furthermore, we will examine possible mechanisms behind basic vulnerability of MA-ergic neurons in AD. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 283 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 280 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 62 | 22% |
| Student > Master | 41 | 14% |
| Researcher | 39 | 14% |
| Student > Bachelor | 22 | 8% |
| Student > Doctoral Student | 17 | 6% |
| Other | 45 | 16% |
| Unknown | 57 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 52 | 18% |
| Medicine and Dentistry | 50 | 18% |
| Agricultural and Biological Sciences | 37 | 13% |
| Psychology | 25 | 9% |
| Biochemistry, Genetics and Molecular Biology | 13 | 5% |
| Other | 36 | 13% |
| Unknown | 70 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2024.
All research outputs
#7,960,052
of 25,374,647 outputs
Outputs from Neuroscience & Biobehavioral Reviews
#2,556
of 4,284 outputs
Outputs of similar age
#64,882
of 207,926 outputs
Outputs of similar age from Neuroscience & Biobehavioral Reviews
#21
of 37 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,284 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.4. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,926 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.