| Title |
Focused Ultrasound: An Emerging Therapeutic Modality for Neurologic Disease
|
|---|---|
| Published in |
Neurotherapeutics, April 2017
|
| DOI | 10.1007/s13311-017-0515-1 |
| Pubmed ID | |
| Authors |
Paul S Fishman, Victor Frenkel |
| Abstract |
Therapeutic ultrasound is only beginning to be applied to neurologic conditions, but the potential of this modality for a wide spectrum of brain applications is high. Engineering advances now allow sound waves to be targeted through the skull to a brain region selected with real time magnetic resonance imaging and thermography, using a commercial array of focused emitters. High intensities of sonic energy can create a coagulation lesion similar to that of older radiofrequency stereotactic methods, but without opening the skull. This has led to the recent Food and Drug Administration approval of focused ultrasound (FUS) thalamotomy for unilateral treatment of essential tremor. Clinical studies of stereotactic FUS for aspects of Parkinson's disease, chronic pain, and refractory psychiatric indications are underway, with promising results. Moderate-intensity FUS has the potential to safely open the blood-brain barrier for localized delivery of therapeutics, while low levels of sonic energy can be used as a form of neuromodulation. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Korea, Republic of | 1 | 25% |
| Canada | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 153 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 14% |
| Student > Bachelor | 21 | 14% |
| Student > Ph. D. Student | 20 | 13% |
| Student > Master | 13 | 8% |
| Other | 8 | 5% |
| Other | 27 | 18% |
| Unknown | 42 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 16% |
| Engineering | 24 | 16% |
| Neuroscience | 23 | 15% |
| Agricultural and Biological Sciences | 9 | 6% |
| Nursing and Health Professions | 4 | 3% |
| Other | 20 | 13% |
| Unknown | 48 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2021.
All research outputs
#15,173,117
of 25,382,440 outputs
Outputs from Neurotherapeutics
#971
of 1,308 outputs
Outputs of similar age
#170,500
of 323,961 outputs
Outputs of similar age from Neurotherapeutics
#10
of 16 outputs
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