Title |
Toxin-induced models of Parkinson’s disease
|
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Published in |
Neurotherapeutics, July 2005
|
DOI | 10.1602/neurorx.2.3.484 |
Pubmed ID | |
Authors |
Jordi Bové, Delphine Prou, Céline Perier, Serge Przedborski |
Abstract |
Parkinson's disease (PD) is a common neurodegenerative disease that appears essentially as a sporadic condition. It results mainly from the death of dopaminergic neurons in the substantia nigra. PD etiology remains mysterious, whereas its pathogenesis begins to be understood as a multifactorial cascade of deleterious factors. Most insights into PD pathogenesis come from investigations performed in experimental models of PD, especially those produced by neurotoxins. Although a host of natural and synthetic molecules do exert deleterious effects on dopaminergic neurons, only a handful are used in living laboratory animals to recapitulate some of the hallmarks of PD. In this review, we discuss what we believe are the four most popular parkinsonian neurotoxins, namely 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), rotenone, and paraquat. The main goal is to provide an updated summary of the main characteristics of each of these four neurotoxins. However, we also try to provide the reader with an idea about the various strengths and the weaknesses of these neurotoxic models. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | <1% |
United Kingdom | 5 | <1% |
Germany | 4 | <1% |
Brazil | 3 | <1% |
Portugal | 2 | <1% |
Canada | 2 | <1% |
Austria | 1 | <1% |
France | 1 | <1% |
Chile | 1 | <1% |
Other | 7 | 1% |
Unknown | 580 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 111 | 18% |
Researcher | 96 | 16% |
Student > Bachelor | 93 | 15% |
Student > Master | 81 | 13% |
Student > Doctoral Student | 35 | 6% |
Other | 82 | 13% |
Unknown | 113 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 157 | 26% |
Neuroscience | 97 | 16% |
Medicine and Dentistry | 75 | 12% |
Biochemistry, Genetics and Molecular Biology | 62 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 32 | 5% |
Other | 52 | 9% |
Unknown | 136 | 22% |