Title |
A Protocol for the Pharmacokinetics of Enteric Coated Mycophenolate Sodium in Lupus Nephritis (POEMSLUN): an open-label, randomised controlled trial
|
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Published in |
BMJ Open, August 2013
|
DOI | 10.1136/bmjopen-2013-003511 |
Pubmed ID | |
Authors |
Dwarakanathan Ranganathan, George T John, Helen Healy, Matthew J Roberts, Robert G Fassett, Jeffrey Lipman, Paul Kubler, Jacobus Ungerer, Brett C McWhinney, Aaron Lim, Megan Purvey, Reza Reyaldeen, Jason A Roberts |
Abstract |
Mycophenolate sodium, an enteric-coated tablet (EC-MPS), is as effective and safe as mycophenolate mofetil (MMF) in preventing transplant rejection. EC-MPS and MMF improve the outcome of severe lupus nephritis (LN) and have fewer side effects than pulsed intravenous cyclophosphamide. Blood concentrations of mycophenolic acid (MPA), the active metabolite of EC-MPS, vary between participants despite fixed dosing. Interpatient variability has been studied in transplantation, but not well documented in LN. The relationship between MPA concentration and its clinical effect on LN has not been described. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 5% |
Unknown | 21 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 3 | 14% |
Student > Ph. D. Student | 2 | 9% |
Professor > Associate Professor | 2 | 9% |
Professor | 2 | 9% |
Student > Master | 2 | 9% |
Other | 6 | 27% |
Unknown | 5 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 41% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Unspecified | 1 | 5% |
Nursing and Health Professions | 1 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Other | 2 | 9% |
Unknown | 6 | 27% |