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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The immune response of the human brain to abdominal surgery
|
|---|---|
| Published in |
Annals of Neurology, April 2017
|
| DOI | 10.1002/ana.24909 |
| Pubmed ID | |
| Authors |
Anton Forsberg, Simon Cervenka, Malin Jonsson Fagerlund, Lars S. Rasmussen, Henrik Zetterberg, Helena Erlandsson Harris, Pernilla Stridh, Eva Christensson, Anna Granström, Anna Schening, Karin Dymmel, Nina Knave, Niccolò Terrando, Mervyn Maze, Jacqueline Borg, Andrea Varrone, Christer Halldin, Kaj Blennow, Lars Farde, Lars I. Eriksson |
| Abstract |
Surgery launches a systemic inflammatory reaction that reaches the brain and associates with immune activation and cognitive decline. While preclinical studies have in part described this systemic-to-brain signaling pathway, we lack information on how these changes appear in humans. This study examines the short- and long-term impact of abdominal surgery on the human brain immune system by Positron Emission Tomography (PET) in relation to blood immune reactivity, plasma inflammatory biomarkers and cognitive function. Eight males undergoing prostatectomy under general anesthesia were included. Prior to surgery (baseline), at postoperative day 3-4 and after 3 months, patients were examined using [(11) C]PBR28 brain PET imaging to assess brain immune cell activation. Concurrently, systemic inflammatory biomarkers, ex vivo blood tests on immunoreactivity to lipopolysaccharide (LPS) stimulation and cognitive function were assessed. Patients showed a global down-regulation of GM [(11) C]PBR28 binding of 26±26% (mean±SD) at 3-4 days postoperatively compared to baseline (p=0.023), recovering or even increasing after 3 months. LPS-induced release of the pro-inflammatory marker TNF-α in blood displayed a reduction (41±39%) on the 3-4(th) postoperative day, corresponding to changes in [(11) C]PBR28 VT . Change in Stroop color word cognitive test performance between postoperative day 3-4 and 3 months correlated to change in [(11) C]PBR28 binding (p=0.027). This study translates preclinical data on changes in the brain immune system after surgery to humans, and suggests an interplay between the human brain and the inflammatory response of the peripheral innate immune system. These findings may be related to post-surgical impairments of cognitive function. This article is protected by copyright. All rights reserved. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| Nigeria | 1 | 20% |
| Australia | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 40% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 77 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 14% |
| Researcher | 11 | 14% |
| Student > Master | 10 | 13% |
| Other | 7 | 9% |
| Student > Doctoral Student | 5 | 6% |
| Other | 12 | 16% |
| Unknown | 21 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 21% |
| Neuroscience | 11 | 14% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Psychology | 4 | 5% |
| Agricultural and Biological Sciences | 3 | 4% |
| Other | 10 | 13% |
| Unknown | 27 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2023.
All research outputs
#2,296,889
of 25,701,027 outputs
Outputs from Annals of Neurology
#1,063
of 5,621 outputs
Outputs of similar age
#42,001
of 325,527 outputs
Outputs of similar age from Annals of Neurology
#10
of 32 outputs
Altmetric has tracked 25,701,027 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,621 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.9. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,527 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.