| Title |
Epigenetics: a link between addiction and social environment
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, March 2017
|
| DOI | 10.1007/s00018-017-2493-1 |
| Pubmed ID | |
| Authors |
Duyilemi C. Ajonijebu, Oualid Abboussi, Vivienne A. Russell, Musa V. Mabandla, William M. U. Daniels |
| Abstract |
The detrimental effects of drug abuse are apparently not limited to individuals but may also impact the vulnerability of their progenies to develop addictive behaviours. Epigenetic signatures, early life experience and environmental factors, converge to influence gene expression patterns in addiction phenotypes and consequently may serve as mediators of behavioural trait transmission between generations. The majority of studies investigating the role of epigenetics in addiction do not consider the influence of social interactions. This shortcoming in current experimental approaches necessitates developing social models that reflect the addictive behaviour in a free-living social environment. Furthermore, this review also reports on the advancement of interventions for drug addiction and takes into account the emerging roles of histone deacetylase (HDAC) inhibitors in the etiology of drug addiction and that HDAC may be a potential therapeutic target at nucleosomal level to improve treatment outcomes. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 150 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 1 | <1% |
| Unknown | 149 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 17% |
| Student > Bachelor | 24 | 16% |
| Student > Master | 16 | 11% |
| Researcher | 13 | 9% |
| Student > Doctoral Student | 10 | 7% |
| Other | 23 | 15% |
| Unknown | 39 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 22 | 15% |
| Biochemistry, Genetics and Molecular Biology | 15 | 10% |
| Psychology | 15 | 10% |
| Agricultural and Biological Sciences | 12 | 8% |
| Medicine and Dentistry | 11 | 7% |
| Other | 28 | 19% |
| Unknown | 47 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2019.
All research outputs
#6,422,288
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#1,351
of 4,151 outputs
Outputs of similar age
#101,102
of 312,166 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#15
of 55 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,166 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.