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An antimicrobial peptide-resistant minor subpopulation of Photorhabdus luminescens is responsible for virulence

Overview of attention for article published in Scientific Reports, March 2017
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Title
An antimicrobial peptide-resistant minor subpopulation of Photorhabdus luminescens is responsible for virulence
Published in
Scientific Reports, March 2017
DOI 10.1038/srep43670
Pubmed ID
Authors

Annabelle Mouammine, Sylvie Pages, Anne Lanois, Sophie Gaudriault, Gregory Jubelin, Maurine Bonabaud, Stéphane Cruveiller, Emeric Dubois, David Roche, Ludovic Legrand, Julien Brillard, Alain Givaudan

Abstract

Some of the bacterial cells in isogenic populations behave differently from others. We describe here how a new type of phenotypic heterogeneity relating to resistance to cationic antimicrobial peptides (CAMPs) is determinant for the pathogenic infection process of the entomopathogenic bacterium Photorhabdus luminescens. We demonstrate that the resistant subpopulation, which accounts for only 0.5% of the wild-type population, causes septicemia in insects. Bacterial heterogeneity is driven by the PhoPQ two-component regulatory system and expression of pbgPE, an operon encoding proteins involved in lipopolysaccharide (LPS) modifications. We also report the characterization of a core regulon controlled by the DNA-binding PhoP protein, which governs virulence in P. luminescens. Comparative RNAseq analysis revealed an upregulation of marker genes for resistance, virulence and bacterial antagonism in the pre-existing resistant subpopulation, suggesting a greater ability to infect insect prey and to survive in cadavers. Finally, we suggest that the infection process of P. luminescens is based on a bet-hedging strategy to cope with the diverse environmental conditions experienced during the lifecycle.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 2%
Unknown 58 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 22%
Student > Ph. D. Student 11 19%
Student > Master 7 12%
Student > Doctoral Student 4 7%
Other 3 5%
Other 5 8%
Unknown 16 27%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 32%
Immunology and Microbiology 9 15%
Biochemistry, Genetics and Molecular Biology 6 10%
Veterinary Science and Veterinary Medicine 2 3%
Medicine and Dentistry 2 3%
Other 5 8%
Unknown 16 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2018.
All research outputs
#14,053,608
of 22,958,253 outputs
Outputs from Scientific Reports
#64,886
of 123,956 outputs
Outputs of similar age
#170,528
of 310,726 outputs
Outputs of similar age from Scientific Reports
#2,428
of 4,587 outputs
Altmetric has tracked 22,958,253 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 123,956 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,726 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,587 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.