| Title |
Alteration of regional homogeneity and white matter hyperintensities in amnestic mild cognitive impairment subtypes are related to cognition and CSF biomarkers
|
|---|---|
| Published in |
Brain Imaging and Behavior, February 2017
|
| DOI | 10.1007/s11682-017-9680-4 |
| Pubmed ID | |
| Authors |
Xiao Luo, Yerfan Jiaerken, Peiyu Huang, Xiao Jun Xu, Tiantian Qiu, Yunlu Jia, Zhujing Shen, Xiaojun Guan, Jiong Zhou, Minming Zhang, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI) |
| Abstract |
Amnestic mild cognitive impairment can be further classified as single-domain aMCI (SD-aMCI) with isolated memory deficit, or multi-domain aMCI (MD-aMCI) if memory deficit is combined with impairment in other cognitive domains. Prior studies reported these clinical subtypes presumably differ in etiology. Thus, we aimed to explore the possible mechanisms between different aMCI subtypes by assessing alteration in brain activity and brain vasculature, and their relations with CSF AD biomarkers. 49 healthy controls, 32 SD-aMCI, and 32 MD-aMCI, who had undergone structural scans, resting-state functional MRI (rsfMRI) scans and neuropsychological evaluations, were identified. Regional homogeneity (ReHo) was employed to analyze regional synchronization. Periventricular white matter hyperintensities (PWMH) and deep WMH (DWMH) volume of each participant was quantitatively assessed. AD biomarkers from CSF were also measured. SD-aMCI showed decreased ReHo in medial temporal gyrus (MTG), and increased ReHo in lingual gyrus (LG) and superior temporal gyrus (STG) relative to controls. MD-aMCI showed decreased ReHo, mostly located in precuneus (PCu), LG and postcentral gyrus (PCG), relative to SD-aMCI and controls. As for microvascular disease, MD-aMCI patients had more PWMH burden than SD-aMCI and controls. Correlation analyses indicated mean ReHo in differenced regions were related with memory, language, and executive function in aMCI patients. However, no significant associations between PWMH and behavioral data were found. The Aβ level was related with the ReHo value of STG in SD-aMCI. MD-aMCI displayed different patterns of abnormal regional synchronization and more severe PWMH burden compared with SD-aMCI. Therefore aMCI is not a uniform disease entity, and MD-aMCI group may show more complicated pathologies than SD-aMCI group. |
Mendeley readers
The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 87 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 14% |
| Student > Ph. D. Student | 10 | 11% |
| Researcher | 6 | 7% |
| Other | 6 | 7% |
| Student > Doctoral Student | 5 | 6% |
| Other | 11 | 13% |
| Unknown | 37 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 17 | 20% |
| Medicine and Dentistry | 12 | 14% |
| Psychology | 10 | 11% |
| Computer Science | 2 | 2% |
| Engineering | 2 | 2% |
| Other | 4 | 5% |
| Unknown | 40 | 46% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2017.
All research outputs
#4,209,584
of 22,958,253 outputs
Outputs from Brain Imaging and Behavior
#234
of 1,155 outputs
Outputs of similar age
#76,162
of 311,651 outputs
Outputs of similar age from Brain Imaging and Behavior
#8
of 35 outputs
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So far Altmetric has tracked 1,155 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done well, scoring higher than 75% of its peers.
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We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.