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Mendeley readers
Attention Score in Context
| Title |
Toward aggregation-resistant antibodies by design
|
|---|---|
| Published in |
Trends in Biotechnology, August 2013
|
| DOI | 10.1016/j.tibtech.2013.07.002 |
| Pubmed ID | |
| Authors |
Christine C. Lee, Joseph M. Perchiacca, Peter M. Tessier |
| Abstract |
Monoclonal antibodies are attractive therapeutics for treating a wide range of human disorders due to their exquisite binding specificity and high binding affinity. However, a limitation of antibodies is their highly variable and difficult-to-predict propensities to aggregate when concentrated during purification and delivery. Despite the large size and complex structure of antibodies, recent findings suggest that antibody solubility can be dramatically improved using rational design methods in addition to conventional selection methods. Here, we review key advances and unmet challenges in engineering the variable and constant regions of antibody fragments and full-length antibodies to resist aggregation without reducing their binding affinity. These experimental and computational discoveries should accelerate the development of robust algorithms for designing aggregation-resistant antibodies. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 67% |
| United Kingdom | 1 | 17% |
| Unknown | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Scientists | 1 | 17% |
| Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 245 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| Germany | 2 | <1% |
| United Kingdom | 2 | <1% |
| France | 1 | <1% |
| Switzerland | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 234 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 76 | 31% |
| Student > Ph. D. Student | 53 | 22% |
| Other | 23 | 9% |
| Student > Master | 23 | 9% |
| Student > Bachelor | 19 | 8% |
| Other | 31 | 13% |
| Unknown | 20 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 89 | 36% |
| Biochemistry, Genetics and Molecular Biology | 57 | 23% |
| Chemistry | 16 | 7% |
| Engineering | 15 | 6% |
| Chemical Engineering | 11 | 4% |
| Other | 33 | 13% |
| Unknown | 24 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2020.
All research outputs
#5,405,477
of 25,374,647 outputs
Outputs from Trends in Biotechnology
#1,088
of 2,856 outputs
Outputs of similar age
#43,841
of 208,918 outputs
Outputs of similar age from Trends in Biotechnology
#9
of 14 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,856 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,918 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.