| Title |
Interaction of endothelial cells with macrophages—linking molecular and metabolic signaling
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, February 2017
|
| DOI | 10.1007/s00424-017-1946-6 |
| Pubmed ID | |
| Authors |
Joanna Kalucka, Laura Bierhansl, Ben Wielockx, Peter Carmeliet, Guy Eelen |
| Abstract |
Angiogenesis and inflammation go hand in hand in various (patho-)physiological conditions. Several studies have highlighted the interconnection between endothelial cells (ECs) and macrophages in these conditions at the level of growth factor and cytokine signaling, yet the importance of metabolism and metabolic signaling has been largely overlooked. Modulating macrophage and/or endothelial functions by interfering with metabolic pathways offers new perspectives for therapeutic strategies. In this review, we highlight the complexity of the interrelationship between the inflammatory response and angiogenesis. More in particular, the interaction between macrophages and ECs will be discussed with a special focus on how their metabolism can contribute to (patho-)physiological conditions. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 1 | 20% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 78 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 23% |
| Student > Master | 13 | 16% |
| Student > Bachelor | 9 | 11% |
| Researcher | 7 | 9% |
| Student > Postgraduate | 5 | 6% |
| Other | 14 | 18% |
| Unknown | 14 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 26% |
| Biochemistry, Genetics and Molecular Biology | 19 | 24% |
| Medicine and Dentistry | 8 | 10% |
| Engineering | 5 | 6% |
| Immunology and Microbiology | 3 | 4% |
| Other | 8 | 10% |
| Unknown | 16 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2017.
All research outputs
#13,227,940
of 23,818,521 outputs
Outputs from Pflügers Archiv - European Journal of Physiology
#1,173
of 1,973 outputs
Outputs of similar age
#150,115
of 313,196 outputs
Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#15
of 23 outputs
Altmetric has tracked 23,818,521 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,973 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,196 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.