↓ Skip to main content

Inflammatory cytokine and microRNA responses of primary human dendritic cells cultured with Helicobacter pylori strains

Overview of attention for article published in Frontiers in Microbiology, January 2013
Altmetric Badge

Mentioned by

twitter
1 X user

Citations

dimensions_citation
32 Dimensions

Readers on

mendeley
33 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Inflammatory cytokine and microRNA responses of primary human dendritic cells cultured with Helicobacter pylori strains
Published in
Frontiers in Microbiology, January 2013
DOI 10.3389/fmicb.2013.00236
Pubmed ID
Authors

Anaïs Hocès de la Guardia, Cathy Staedel, Itidal Kaafarany, Aurélien Clément, Claire Roubaud Baudron, Francis Mégraud, Philippe Lehours

Abstract

Primary human dendritic cells (DC) were used to explore the inflammatory effectors, including cytokines and microRNAs, regulated by Helicobacter pylori. In a 48 h ex-vivo co-culture system, both H. pylori B38 and B45 strains activated human DCs and promoted a strong inflammatory response characterized by the early production of pro-inflammatory TNFα and IL-6 cytokines, followed by IL-10, IL-1β, and IL-23 secretion. IL-23 was the only cytokine dependent on the cag pathogenicity island status of the bacterial strains. DC activation and cytokine production were accompanied by an early miR-146a upregulation followed by a strong miR-155 induction, which mainly controlled TNFα production. These results pave the way for further investigations into the nature of H. pylori antigens and the subsequently activated signaling pathways involved in the inflammatory response to H. pylori infection, the deregulation of which may likely contribute to gastric lymphomagenesis.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Sri Lanka 1 3%
Unknown 32 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 30%
Researcher 8 24%
Student > Bachelor 5 15%
Student > Doctoral Student 1 3%
Student > Master 1 3%
Other 3 9%
Unknown 5 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 36%
Immunology and Microbiology 6 18%
Medicine and Dentistry 5 15%
Biochemistry, Genetics and Molecular Biology 1 3%
Social Sciences 1 3%
Other 1 3%
Unknown 7 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2013.
All research outputs
#20,198,525
of 22,716,996 outputs
Outputs from Frontiers in Microbiology
#22,160
of 24,561 outputs
Outputs of similar age
#248,774
of 280,757 outputs
Outputs of similar age from Frontiers in Microbiology
#264
of 407 outputs
Altmetric has tracked 22,716,996 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,561 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,757 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 407 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.