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Plasmodium falciparum gametocytes: with a view to a kill

Overview of attention for article published in Parasitology, August 2013
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Title
Plasmodium falciparum gametocytes: with a view to a kill
Published in
Parasitology, August 2013
DOI 10.1017/s0031182013001236
Pubmed ID
Authors

ALICE S. BUTTERWORTH, TINA S. SKINNER-ADAMS, DON L. GARDINER, KATHARINE R. TRENHOLME

Abstract

Drugs that kill or inhibit the sexual stages of Plasmodium in order to prevent transmission are important components of malaria control programmes. Reducing gametocyte carriage is central to the control of Plasmodium falciparum transmission as infection can result in extended periods of gametocytaemia. Unfortunately the number of drugs with activity against gametocytes is limited. Primaquine is currently the only licensed drug with activity against the sexual stages of malaria parasites and its use is hampered by safety concerns. This shortcoming is likely the result of the technical challenges associated with gametocyte studies together with the focus of previous drug discovery campaigns on asexual parasite stages. However recent emphasis on malaria eradication has resulted in an upsurge of interest in identifying compounds with activity against gametocytes. This review examines the gametocytocidal properties of currently available drugs as well as those in the development pipeline and examines the prospects for discovery of new anti-gametocyte compounds.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Brazil 1 1%
Unknown 88 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 23%
Researcher 20 22%
Student > Bachelor 10 11%
Student > Master 10 11%
Student > Postgraduate 5 6%
Other 9 10%
Unknown 15 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 29%
Biochemistry, Genetics and Molecular Biology 13 14%
Medicine and Dentistry 10 11%
Pharmacology, Toxicology and Pharmaceutical Science 6 7%
Immunology and Microbiology 6 7%
Other 10 11%
Unknown 19 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2013.
All research outputs
#17,348,916
of 25,457,858 outputs
Outputs from Parasitology
#2,054
of 2,817 outputs
Outputs of similar age
#132,402
of 209,988 outputs
Outputs of similar age from Parasitology
#17
of 28 outputs
Altmetric has tracked 25,457,858 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,817 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,988 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.