Title |
Identification of a KCNQ1 Polymorphism Acting as a Protective Modifier Against Arrhythmic Risk in Long-QT Syndrome
|
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Published in |
Circulation: Genomic and Precision Medicine, July 2013
|
DOI | 10.1161/circgenetics.113.000023 |
Pubmed ID | |
Authors |
Sabine Duchatelet, Lia Crotti, Rachel A. Peat, Isabelle Denjoy, Hideki Itoh, Myriam Berthet, Seiko Ohno, Véronique Fressart, Maria Cristina Monti, Cristina Crocamo, Matteo Pedrazzini, Federica Dagradi, Alessandro Vicentini, Didier Klug, Paul A. Brink, Althea Goosen, Heikki Swan, Lauri Toivonen, Annukka M. Lahtinen, Kimmo Kontula, Wataru Shimizu, Minoru Horie, Alfred L. George, David-Alexandre Trégouët, Pascale Guicheney, Peter J. Schwartz |
Abstract |
Long-QT syndrome (LQTS) is characterized by such striking clinical heterogeneity that, even among family members carrying the same mutation, clinical outcome can range between sudden death and no symptoms. We investigated the role of genetic variants as modifiers of risk for cardiac events in patients with LQTS. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
Germany | 1 | 25% |
Australia | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Finland | 1 | 1% |
United Kingdom | 1 | 1% |
Unknown | 69 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 24% |
Researcher | 11 | 15% |
Student > Master | 7 | 10% |
Professor | 7 | 10% |
Other | 6 | 8% |
Other | 11 | 15% |
Unknown | 12 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 37% |
Biochemistry, Genetics and Molecular Biology | 13 | 18% |
Agricultural and Biological Sciences | 7 | 10% |
Business, Management and Accounting | 2 | 3% |
Unspecified | 1 | 1% |
Other | 5 | 7% |
Unknown | 17 | 24% |