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Mendeley readers
Attention Score in Context
| Title |
In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide
|
|---|---|
| Published in |
Journal of the American Chemical Society, July 2013
|
| DOI | 10.1021/ja405108p |
| Pubmed ID | |
| Authors |
Yanbin Ji, Subhabrata Majumder, Melissa Millard, Radhika Borra, Tao Bi, Ahmed Y. Elnagar, Nouri Neamati, Alexander Shekhtman, Julio A. Camarero |
| Abstract |
The overexpression of Hdm2 and HdmX is a common mechanism used by many tumor cells to inactive the p53 tumor suppressor pathway promoting cell survival. Targeting Hdm2 and HdmX has emerged as a validated therapeutic strategy for treating cancers with wild-type p53. Small linear peptides mimicking the N-terminal fragment of p53 have been shown to be potent Hdm2/HdmX antagonists. The potential therapeutic use of these peptides, however, is limited by their poor stability and bioavailability. Here, we report the engineering of the cyclotide MCoTI-I to efficiently antagonize intracellular p53 degradation. The resulting cyclotide MCo-PMI was able to bind with low nanomolar affinity to both Hdm2 and HdmX, showed high stability in human serum, and was cytotoxic to wild-type p53 cancer cell lines by activating the p53 tumor suppressor pathway both in vitro and in vivo. These features make the cyclotide MCoTI-I an optimal scaffold for targeting intracellular protein-protein interactions. |
Mendeley readers
The data shown below were compiled from readership statistics for 160 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 158 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 51 | 32% |
| Researcher | 33 | 21% |
| Student > Master | 12 | 8% |
| Professor > Associate Professor | 9 | 6% |
| Student > Doctoral Student | 8 | 5% |
| Other | 26 | 16% |
| Unknown | 21 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 63 | 39% |
| Biochemistry, Genetics and Molecular Biology | 26 | 16% |
| Agricultural and Biological Sciences | 23 | 14% |
| Medicine and Dentistry | 6 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Other | 14 | 9% |
| Unknown | 25 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2023.
All research outputs
#6,633,898
of 23,445,423 outputs
Outputs from Journal of the American Chemical Society
#26,634
of 63,016 outputs
Outputs of similar age
#55,826
of 199,826 outputs
Outputs of similar age from Journal of the American Chemical Society
#231
of 552 outputs
Altmetric has tracked 23,445,423 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 63,016 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 199,826 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 552 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.