| Title |
Gastrointestinal symptoms predictors of health-related quality of life in pediatric patients with functional gastrointestinal disorders
|
|---|---|
| Published in |
Quality of Life Research, October 2016
|
| DOI | 10.1007/s11136-016-1430-3 |
| Pubmed ID | |
| Authors |
James W. Varni, Robert J. Shulman, Mariella M. Self, Samuel Nurko, Miguel Saps, Shehzad A. Saeed, Ashish S. Patel, Chelsea Vaughan Dark, Cristiane B. Bendo, John F. Pohl, on behalf of the Pediatric Quality of Life Inventory™ Gastrointestinal Symptoms Module Testing Study Consortium |
| Abstract |
To investigate the patient-reported multidimensional gastrointestinal symptoms predictors of generic health-related quality of life (HRQOL) in pediatric patients with functional gastrointestinal disorders (FGIDs). The Pediatric Quality of Life Inventory™ (PedsQL™) Gastrointestinal Symptoms Scales and PedsQL™ 4.0 Generic Core Scales were completed in a 9-site study by 259 pediatric patients with functional constipation, functional abdominal pain (FAP), or irritable bowel syndrome (IBS). Gastrointestinal Symptoms Scales measuring stomach pain, stomach discomfort when eating, food and drink limits, trouble swallowing, heartburn and reflux, nausea and vomiting, gas and bloating, constipation, blood in poop, and diarrhea were identified as clinically important symptom differentiators from healthy controls based on prior findings, and subsequently tested for bivariate and multivariate linear associations with overall HRQOL. Gastrointestinal symptoms were differentially associated with decreased HRQOL in bivariate analyses for the three FGIDs. In predictive models utilizing hierarchical multiple regression analyses controlling for age, gender, and race/ethnicity, gastrointestinal symptoms differentially accounted for an additional 47, 40, and 60 % of the variance in patient-reported HRQOL for functional constipation, FAP, and IBS, respectively, reflecting large effect sizes. Significant individual gastrointestinal symptoms predictors were identified after controlling for the other gastrointestinal symptoms in the FGID-specific predictive models. Gastrointestinal symptoms represent potentially modifiable predictors of generic HRQOL in pediatric patients with FGIDs. Identifying the condition-specific gastrointestinal symptoms that are the most important predictors from the patient perspective facilitates a patient-centered approach to targeted interventions designed to ameliorate impaired overall HRQOL. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 67% |
| United States | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 77 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 10% |
| Student > Bachelor | 7 | 9% |
| Student > Ph. D. Student | 6 | 8% |
| Other | 5 | 6% |
| Researcher | 5 | 6% |
| Other | 17 | 22% |
| Unknown | 29 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 26% |
| Psychology | 10 | 13% |
| Nursing and Health Professions | 4 | 5% |
| Agricultural and Biological Sciences | 2 | 3% |
| Sports and Recreations | 2 | 3% |
| Other | 5 | 6% |
| Unknown | 34 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2017.
All research outputs
#14,728,795
of 24,701,106 outputs
Outputs from Quality of Life Research
#1,477
of 3,033 outputs
Outputs of similar age
#175,110
of 325,890 outputs
Outputs of similar age from Quality of Life Research
#27
of 66 outputs
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