| Title |
Molecular Physiology of Mammalian Glucokinase
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, August 2008
|
| DOI | 10.1007/s00018-008-8322-9 |
| Pubmed ID | |
| Authors |
P. B. Iynedjian |
| Abstract |
The glucokinase (GCK) gene was one of the first candidate genes to be identified as a human "diabetes gene". Subsequently, important advances were made in understanding the impact of GCK in the regulation of glucose metabolism. Structure elucidation by crystallography provided insight into the kinetic properties of GCK. Protein interaction partners of GCK were discovered. Gene expression studies revealed new facets of the tissue distribution of GCK, including in the brain, and its regulation by insulin in the liver. Metabolic control analysis coupled to gene overexpression and knockout experiments highlighted the unique impact of GCK as a regulator of glucose metabolism. Human GCK mutants were studied biochemically to understand disease mechanisms. Drug development programs identified small molecule activators of GCK as potential antidiabetics. These advances are summarized here, with the aim of offering an integrated view of the role of GCK in the molecular physiology and medicine of glucose homeostasis. |
Mendeley readers
The data shown below were compiled from readership statistics for 214 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Germany | 1 | <1% |
| Italy | 1 | <1% |
| Portugal | 1 | <1% |
| Russia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Croatia | 1 | <1% |
| Philippines | 1 | <1% |
| Unknown | 204 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 43 | 20% |
| Researcher | 36 | 17% |
| Student > Bachelor | 25 | 12% |
| Student > Master | 21 | 10% |
| Student > Doctoral Student | 10 | 5% |
| Other | 39 | 18% |
| Unknown | 40 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 61 | 29% |
| Biochemistry, Genetics and Molecular Biology | 52 | 24% |
| Medicine and Dentistry | 23 | 11% |
| Chemistry | 9 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 4% |
| Other | 16 | 7% |
| Unknown | 45 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 June 2023.
All research outputs
#7,591,533
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#1,602
of 4,151 outputs
Outputs of similar age
#30,773
of 86,284 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#16
of 32 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 86,284 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.