You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice
|
|---|---|
| Published in |
Cerebral Cortex, August 2013
|
| DOI | 10.1093/cercor/bht202 |
| Pubmed ID | |
| Authors |
Ana Belen Lopez-Rodriguez, Eleni Siopi, David P. Finn, Catherine Marchand-Leroux, Luis M. Garcia-Segura, Mehrnaz Jafarian-Tehrani, Maria-Paz Viveros |
| Abstract |
Traumatic brain injury (TBI) and its consequences represent one of the leading causes of death in young adults. This lesion mediates glial activation and the release of harmful molecules and causes brain edema, axonal injury, and functional impairment. Since glial activation plays a key role in the development of this damage, it seems that controlling it could be beneficial and could lead to neuroprotective effects. Recent studies show that minocycline suppresses microglial activation, reduces the lesion volume, and decreases TBI-induced locomotor hyperactivity up to 3 months. The endocannabinoid system (ECS) plays an important role in reparative mechanisms and inflammation under pathological situations by controlling some mechanisms that are shared with minocycline pathways. We hypothesized that the ECS could be involved in the neuroprotective effects of minocycline. To address this hypothesis, we used a murine TBI model in combination with selective CB1 and CB2 receptor antagonists (AM251 and AM630, respectively). The results provided the first evidence for the involvement of ECS in the neuroprotective action of minocycline on brain edema, neurological impairment, diffuse axonal injury, and microglial activation, since all these effects were prevented by the CB1 and CB2 receptor antagonists. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 30% |
| Canada | 1 | 5% |
| Brazil | 1 | 5% |
| Haiti | 1 | 5% |
| Georgia | 1 | 5% |
| Netherlands | 1 | 5% |
| Unknown | 9 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 80% |
| Scientists | 2 | 10% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
| Unknown | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 98 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 21% |
| Student > Bachelor | 15 | 15% |
| Researcher | 14 | 14% |
| Student > Master | 9 | 9% |
| Student > Doctoral Student | 5 | 5% |
| Other | 16 | 16% |
| Unknown | 21 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 23 | 23% |
| Agricultural and Biological Sciences | 16 | 16% |
| Biochemistry, Genetics and Molecular Biology | 8 | 8% |
| Medicine and Dentistry | 8 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Other | 13 | 13% |
| Unknown | 30 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 103. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2024.
All research outputs
#406,495
of 25,271,884 outputs
Outputs from Cerebral Cortex
#120
of 5,190 outputs
Outputs of similar age
#2,954
of 205,845 outputs
Outputs of similar age from Cerebral Cortex
#4
of 64 outputs
Altmetric has tracked 25,271,884 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,190 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.2. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 205,845 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.