You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
|
|---|---|
| Published in |
Nature Genetics, August 2013
|
| DOI | 10.1038/ng.2742 |
| Pubmed ID | |
| Authors |
Peter Donnelly, Ines Barroso, Jenefer M Blackwell, Elvira Bramon, Matthew A Brown, Juan P Casas, Aiden P Corvin, Panos Deloukas, Audrey Duncanson, Janusz Jankowski, Hugh S Markus, Christopher G Mathew, Colin N A Palmer, Robert Plomin, Anna Rautanen, Stephen J Sawcer, Richard C Trembath, Ananth C Viswanathan, Nicholas W Wood, Chris C A Spencer, Gavin Band, Céline Bellenguez, Colin Freeman, Garrett Hellenthal, Eleni Giannoulatou, Matti Pirinen, Richard D Pearson, Amy Strange, Zhan Su, Damjan Vukcevic, Peter Donnelly, Cordelia Langford, Sarah E Hunt, Sarah Edkins, Rhian Gwilliam, Hannah Blackburn, Suzannah J Bumpstead, Serge Dronov, Matthew Gillman, Emma Gray, Naomi Hammond, Alagurevathi Jayakumar, Owen T McCann, Jennifer Liddle, Simon C Potter, Radhi Ravindrarajah, Michelle Ricketts, Avazeh Tashakkori-Ghanbaria, Matthew J Waller, Paul Weston, Sara Widaa, Pamela Whittaker, Ines Barroso, Panos Deloukas, Christopher G Mathew, Jenefer M Blackwell, Matthew A Brown, Aiden P Corvin, Mark I McCarthy, Chris C A Spencer |
| Abstract |
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder. |
X Demographics
The data shown below were collected from the profiles of 63 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 21 | 33% |
| United Kingdom | 9 | 14% |
| France | 3 | 5% |
| Ireland | 2 | 3% |
| Saudi Arabia | 2 | 3% |
| Japan | 2 | 3% |
| Colombia | 1 | 2% |
| Spain | 1 | 2% |
| Australia | 1 | 2% |
| Other | 6 | 10% |
| Unknown | 15 | 24% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 33 | 52% |
| Scientists | 18 | 29% |
| Practitioners (doctors, other healthcare professionals) | 10 | 16% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,338 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 14 | 1% |
| United Kingdom | 13 | <1% |
| Germany | 4 | <1% |
| Italy | 4 | <1% |
| Spain | 3 | <1% |
| Portugal | 2 | <1% |
| Netherlands | 2 | <1% |
| Brazil | 2 | <1% |
| Finland | 2 | <1% |
| Other | 12 | <1% |
| Unknown | 1280 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 247 | 18% |
| Researcher | 238 | 18% |
| Student > Bachelor | 168 | 13% |
| Student > Master | 141 | 11% |
| Student > Doctoral Student | 73 | 5% |
| Other | 241 | 18% |
| Unknown | 230 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 331 | 25% |
| Medicine and Dentistry | 185 | 14% |
| Neuroscience | 160 | 12% |
| Biochemistry, Genetics and Molecular Biology | 159 | 12% |
| Psychology | 107 | 8% |
| Other | 115 | 9% |
| Unknown | 281 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 370. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2022.
All research outputs
#86,345
of 25,837,817 outputs
Outputs from Nature Genetics
#126
of 7,639 outputs
Outputs of similar age
#516
of 215,287 outputs
Outputs of similar age from Nature Genetics
#3
of 81 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,639 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 215,287 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.