| Title |
Therapeutic effect of β-blockers in triple-negative breast cancer postmenopausal women
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, August 2013
|
| DOI | 10.1007/s10549-013-2654-3 |
| Pubmed ID | |
| Authors |
Edoardo Botteri, Elisabetta Munzone, Nicole Rotmensz, Carlo Cipolla, Vincenzo De Giorgi, Barbara Santillo, Arnaldo Zanelotti, Laura Adamoli, Marco Colleoni, Giuseppe Viale, Aron Goldhirsch, Sara Gandini |
| Abstract |
Beta-blockers (BB) drugs have been used for decades worldwide, mainly to treat hypertension. However, in recent epidemiological studies, BBs were suggested to improve cancer prognosis. In the wake of this evidence, we evaluated the possible therapeutic effect of BBs in triple-negative breast cancer (TNBC) patients. We identified 800 postmenopausal women operated between 1997 and 2008 for early primary TNBC. The effect of BB intake on the risk of breast cancer (BC) recurrence and death was evaluated through competing risk and Cox regression survival models. At cancer diagnosis, 74 (9.3 %) women out of 800 were BBs users. Median age was 62 years in BB users and 59 years in non-users (P = 0.02). BB users and non-users were similarly distributed by all tumor characteristics. The 5-year cumulative incidence of BC-related events was 13.6 % in BB users and 27.9 % in non-users (P = 0.02). The beneficial impact of BBs remained statistically significant at multivariable analysis (HR, 0.52; 95 % CI 0.28-0.97), after the adjustment for age, tumor stage, and treatment, peritumoral vascular invasion and use of other antihypertensive drugs, antithrombotics, and statins. Adjusted HRs for metastases and for BC deaths were 0.32 (95 % CI 0.12-0.90) and 0.42 (95 % CI 0.18-0.97), respectively, in favor of BBs. Hypertension, other antihypertensive drugs, antithrombotics, and statins did not impact prognosis. In this series of postmenopausal TNBC patients, BB intake was associated with a significantly decreased risk of BC-related recurrence, metastasis, and BC death. Innovative therapeutic strategies including BBs should be urgently explored in cancer patients. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 25% |
| Denmark | 1 | 13% |
| Sweden | 1 | 13% |
| Unknown | 4 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 88% |
| Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| Chile | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 82 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 21% |
| Student > Bachelor | 11 | 13% |
| Student > Master | 10 | 12% |
| Student > Ph. D. Student | 6 | 7% |
| Student > Doctoral Student | 4 | 5% |
| Other | 15 | 18% |
| Unknown | 21 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 32% |
| Biochemistry, Genetics and Molecular Biology | 9 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
| Nursing and Health Professions | 4 | 5% |
| Agricultural and Biological Sciences | 4 | 5% |
| Other | 13 | 15% |
| Unknown | 24 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 43. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2023.
All research outputs
#861,958
of 23,726,221 outputs
Outputs from Breast Cancer Research and Treatment
#88
of 4,776 outputs
Outputs of similar age
#7,501
of 199,950 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#4
of 41 outputs
Altmetric has tracked 23,726,221 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,776 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.