| Title |
A Non-transgenic Mouse Model (icv-STZ Mouse) of Alzheimer’s Disease: Similarities to and Differences from the Transgenic Model (3xTg-AD Mouse)
|
|---|---|
| Published in |
Molecular Neurobiology, November 2012
|
| DOI | 10.1007/s12035-012-8375-5 |
| Pubmed ID | |
| Authors |
Yanxing Chen, Zhihou Liang, Julie Blanchard, Chun-Ling Dai, Shenggang Sun, Moon H. Lee, Inge Grundke-Iqbal, Khalid Iqbal, Fei Liu, Cheng-Xin Gong |
| Abstract |
Alzheimer's disease (AD) can be divided into sporadic AD (SAD) and familial AD (FAD). Most AD cases are sporadic and result from multiple etiologic factors, including environmental, genetic, and metabolic factors, whereas FAD is caused by mutations in the presenilins or amyloid-β (Aβ) precursor protein (APP) genes. A commonly used animal model for AD is the 3xTg-AD transgenic mouse model, which harbors mutated presenilin 1, APP, and tau genes and thus represents a model of FAD. There is an unmet need in the field to characterize animal models representing different AD mechanisms, so that potential drugs for SAD can be evaluated preclinically in these animal models. A mouse model generated by intracerebroventricular (icv) administration of streptozocin (STZ), the icv-STZ mouse, shows many aspects of SAD. In this study, we compared the non-cognitive and cognitive behaviors as well as biochemical and immunohistochemical alterations between the icv-STZ mouse and the 3xTg-AD mouse. We found that both mouse models showed increased exploratory activity as well as impaired learning and spatial memory. Both models also demonstrated neuroinflammation, altered synaptic proteins and insulin/IGF-1 (insulin-like growth factor-1) signaling, and increased hyperphosphorylated tau in the brain. The most prominent brain abnormality in the icv-STZ mouse was neuroinflammation, and in the 3xTg-AD mouse it was elevation of hyperphosphorylated tau. These observations demonstrate the behavioral and neuropathological similarities and differences between the icv-STZ mouse and the 3xTg-AD mouse models and will help guide future studies using these two mouse models for the development of AD drugs. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 316 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Macao | 1 | <1% |
| Australia | 1 | <1% |
| India | 1 | <1% |
| United Kingdom | 1 | <1% |
| Mexico | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Croatia | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 307 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 52 | 16% |
| Student > Bachelor | 48 | 15% |
| Student > Master | 43 | 14% |
| Researcher | 32 | 10% |
| Student > Doctoral Student | 16 | 5% |
| Other | 53 | 17% |
| Unknown | 72 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 58 | 18% |
| Medicine and Dentistry | 44 | 14% |
| Agricultural and Biological Sciences | 36 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 34 | 11% |
| Biochemistry, Genetics and Molecular Biology | 30 | 9% |
| Other | 32 | 10% |
| Unknown | 82 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2023.
All research outputs
#7,099,043
of 24,682,395 outputs
Outputs from Molecular Neurobiology
#1,363
of 3,773 outputs
Outputs of similar age
#49,492
of 183,198 outputs
Outputs of similar age from Molecular Neurobiology
#6
of 14 outputs
Altmetric has tracked 24,682,395 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 3,773 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has gotten more attention than average, scoring higher than 62% of its peers.
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.