| Title |
Disease-free survival by treatment after a DCIS diagnosis in a population-based cohort study
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, August 2013
|
| DOI | 10.1007/s10549-013-2670-3 |
| Pubmed ID | |
| Authors |
Brian L. Sprague, Vicki McLaughlin, John M. Hampton, Polly A. Newcomb, Amy Trentham-Dietz |
| Abstract |
Randomized trials have demonstrated the efficacy of radiation and tamoxifen in reducing risk of second events after breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS), but the comparative effectiveness of mastectomy, BCS, and adjuvant treatments have not been established in community practice. We examined disease-free survival (DFS) among 1,676 DCIS cases diagnosed during 1995-2006 in the population-based Wisconsin In Situ Cohort study. Information on patient and tumor characteristics, treatments, and second breast cancer events were collected via a comprehensive review of data from patient interviews, the statewide cancer registry, and pathology reports. Breast cancer DFS was evaluated according to treatment while adjusting for patient and tumor characteristics. After an average of 7.1 years of follow-up, 143 second breast cancer events occurred. Overall 5-year DFS was similar among women treated with ipsilateral mastectomy (95.6 %; 95 % CI 93.5-97.0) compared to women treated with BCS and radiation (94.8 %; 95 % CI 92.8-96.1), though women receiving BCS without radiation experienced poorer overall DFS (87.0 %; 95 % CI 80.6-91.5). Women treated with tamoxifen in addition to BCS and radiation had a similar risk of a second breast event, although the hazard ratio (HR) suggested a potential benefit (0.70, 95% CI 0.41-1.19). Women treated with BCS, radiation, and tamoxifen had comparable risk of a second event as those treated with ipsilateral mastectomy (HR = 1.20; 95 % CI 0.71-2.02). In this population-based sample, the use of BCS with radiation and tamoxifen resulted in high DFS rates comparable to those achieved by ipsilateral mastectomy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 55 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 33% |
| Student > Master | 9 | 16% |
| Other | 8 | 15% |
| Student > Ph. D. Student | 5 | 9% |
| Student > Bachelor | 3 | 5% |
| Other | 4 | 7% |
| Unknown | 8 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 33% |
| Agricultural and Biological Sciences | 9 | 16% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Psychology | 3 | 5% |
| Nursing and Health Professions | 2 | 4% |
| Other | 10 | 18% |
| Unknown | 9 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2013.
All research outputs
#18,812,604
of 23,314,015 outputs
Outputs from Breast Cancer Research and Treatment
#3,765
of 4,708 outputs
Outputs of similar age
#150,573
of 200,836 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#32
of 37 outputs
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