| Title |
Immunotherapy for type 1 diabetes
|
|---|---|
| Published in |
Journal of Endocrinological Investigation, March 2017
|
| DOI | 10.1007/s40618-017-0641-y |
| Pubmed ID | |
| Authors |
Davide Frumento, Moufida Ben Nasr, Basset El Essawy, Francesca D’Addio, Gian Vincenzo Zuccotti, Paolo Fiorina |
| Abstract |
Although many approaches have been tested to overcome the insulin dependence caused by the pancreatic β-cells destruction observed in individuals affected by type 1 diabetes (T1D), medical research has largely failed to halt the onset or to reverse T1D. In this work, the state of the art of immunotherapy will be examined, and the most important achievement in the field will be critically discussed. Particularly, we will focus on the clinical aspect, thus avoiding the tedious preclinical work done in NOD mice, which has been so poorly translated to the bedside. Stem cell therapies achieved thus this far the most promising results, while immune ablation and standard immunosuppressants did not maintain the premises of preclinical results. The next step will be to generate a feasible and safe clinical approach in order to cure the thousands of patients affected by T1D. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 57% |
| Italy | 1 | 14% |
| Unknown | 2 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 43% |
| Science communicators (journalists, bloggers, editors) | 2 | 29% |
| Practitioners (doctors, other healthcare professionals) | 1 | 14% |
| Scientists | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 61 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 14 | 23% |
| Other | 7 | 11% |
| Student > Ph. D. Student | 7 | 11% |
| Researcher | 7 | 11% |
| Student > Doctoral Student | 2 | 3% |
| Other | 6 | 10% |
| Unknown | 18 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 28% |
| Biochemistry, Genetics and Molecular Biology | 9 | 15% |
| Agricultural and Biological Sciences | 5 | 8% |
| Immunology and Microbiology | 5 | 8% |
| Nursing and Health Professions | 3 | 5% |
| Other | 4 | 7% |
| Unknown | 18 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2020.
All research outputs
#8,264,793
of 25,382,440 outputs
Outputs from Journal of Endocrinological Investigation
#408
of 1,622 outputs
Outputs of similar age
#124,275
of 323,669 outputs
Outputs of similar age from Journal of Endocrinological Investigation
#5
of 32 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 1,622 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,669 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.