Title |
The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis
|
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Published in |
Diabetologia, August 2013
|
DOI | 10.1007/s00125-013-3022-x |
Pubmed ID | |
Authors |
Bo Liu, Zoheb Hassan, Stefan Amisten, Aileen J. King, James E. Bowe, Guo Cai Huang, Peter M. Jones, Shanta J. Persaud |
Abstract |
Chemokine (C-C motif) ligand 5 (CCL5) acts at C-C chemokine receptors (CCRs) to promote immune cell recruitment to sites of inflammation, but is also an agonist at G-protein-coupled receptor 75 (GPR75), which has very limited homology with CCRs. GPR75 is coupled to Gq to elevate intracellular calcium, so we investigated whether islets express this receptor and whether its activation by CCL5 increases beta cell calcium levels and insulin secretion. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 1% |
Unknown | 66 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 15% |
Researcher | 10 | 15% |
Student > Bachelor | 9 | 13% |
Student > Doctoral Student | 6 | 9% |
Student > Master | 6 | 9% |
Other | 11 | 16% |
Unknown | 15 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 15 | 22% |
Agricultural and Biological Sciences | 14 | 21% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 10% |
Medicine and Dentistry | 5 | 7% |
Neuroscience | 4 | 6% |
Other | 4 | 6% |
Unknown | 18 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 June 2022.
All research outputs
#4,145,101
of 22,663,969 outputs
Outputs from Diabetologia
#1,816
of 5,024 outputs
Outputs of similar age
#36,766
of 200,102 outputs
Outputs of similar age from Diabetologia
#13
of 50 outputs
Altmetric has tracked 22,663,969 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,024 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.6. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 200,102 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.