↓ Skip to main content

The Role of the Major Histocompatibility Complex Region in Cognition and Brain Structure: A Schizophrenia GWAS Follow-Up

Overview of attention for article published in American Journal of Psychiatry, August 2013
Altmetric Badge

Mentioned by

twitter
1 X user

Citations

dimensions_citation
58 Dimensions

Readers on

mendeley
100 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
The Role of the Major Histocompatibility Complex Region in Cognition and Brain Structure: A Schizophrenia GWAS Follow-Up
Published in
American Journal of Psychiatry, August 2013
DOI 10.1176/appi.ajp.2013.12020226
Pubmed ID
Authors

James T.R. Walters, Dan Rujescu, Barbara Franke, Ina Giegling, Alejandro Arias Vásquez, April Hargreaves, Giancarlo Russo, Derek W. Morris, Martine Hoogman, Andrea Da Costa, Valentina Moskvina, Guillén Fernández, Michael Gill, Aiden Corvin, Michael C. O’Donovan, Gary Donohoe, Michael J. Owen

Abstract

OBJECTIVE The authors investigated the effects of recently identified genome-wide significant schizophrenia genetic risk variants on cognition and brain structure. METHOD A panel of six single-nucleotide polymorphisms (SNPs) was selected to represent genome-wide significant loci from three recent genome-wide association studies (GWAS) for schizophrenia and was tested for association with cognitive measures in 346 patients with schizophrenia and 2,342 healthy comparison subjects. Nominally significant results were evaluated for replication in an independent case-control sample. For SNPs showing evidence of association with cognition, associations with brain structural volumes were investigated in a large independent healthy comparison sample. RESULTS Five of the six SNPs showed no significant association with any cognitive measure. One marker in the major histocompatibility complex (MHC) region, rs6904071, showed independent, replicated evidence of association with delayed episodic memory and was significant when both samples were combined. In the combined sample of up to 3,100 individuals, this SNP was associated with widespread effects across cognitive domains, although these additional associations were no longer significant after adjusting for delayed episodic memory. In the large independent structural imaging sample, the same SNP was also associated with decreased hippocampal volume. CONCLUSIONS The authors identified a SNP in the MHC region that was associated with cognitive performance in patients with schizophrenia and healthy comparison subjects. This SNP, rs6904071, showed a replicated association with episodic memory and hippocampal volume. These findings implicate the MHC region in hippocampal structure and functioning, consistent with the role of MHC proteins in synaptic development and function. Follow-up of these results has the potential to provide insights into the pathophysiology of schizophrenia and cognition.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 2%
United States 2 2%
Netherlands 1 1%
Canada 1 1%
United Kingdom 1 1%
Japan 1 1%
Spain 1 1%
Unknown 91 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 24%
Student > Bachelor 15 15%
Student > Master 10 10%
Researcher 9 9%
Student > Postgraduate 7 7%
Other 20 20%
Unknown 15 15%
Readers by discipline Count As %
Medicine and Dentistry 25 25%
Agricultural and Biological Sciences 16 16%
Psychology 15 15%
Neuroscience 10 10%
Biochemistry, Genetics and Molecular Biology 6 6%
Other 8 8%
Unknown 20 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2013.
All research outputs
#18,345,822
of 22,719,618 outputs
Outputs from American Journal of Psychiatry
#6,724
of 7,300 outputs
Outputs of similar age
#148,663
of 198,395 outputs
Outputs of similar age from American Journal of Psychiatry
#44
of 49 outputs
Altmetric has tracked 22,719,618 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,300 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.8. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,395 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.