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Mendeley readers
Attention Score in Context
| Title |
Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease
|
|---|---|
| Published in |
Science, June 2001
|
| DOI | 10.1126/science.1059581 |
| Pubmed ID | |
| Authors |
Chiara Zuccato, Andrea Ciammola, Dorotea Rigamonti, Blair R. Leavitt, Donato Goffredo, Luciano Conti, Marcy E. MacDonald, Robert M. Friedlander, Vincenzo Silani, Michael R. Hayden, Tõnis Timmusk, Simonetta Sipione, Elena Cattaneo |
| Abstract |
Huntingtin is a 350-kilodalton protein of unknown function that is mutated in Huntington's disease (HD), a neurodegenerative disorder. The mutant protein is presumed to acquire a toxic gain of function that is detrimental to striatal neurons in the brain. However, loss of a beneficial activity of wild-type huntingtin may also cause the death of striatal neurons. Here we demonstrate that wild-type huntingtin up-regulates transcription of brain-derived neurotrophic factor (BDNF), a pro-survival factor produced by cortical neurons that is necessary for survival of striatal neurons in the brain. We show that this beneficial activity of huntingtin is lost when the protein becomes mutated, resulting in decreased production of cortical BDNF. This leads to insufficient neurotrophic support for striatal neurons, which then die. Restoring wild-type huntingtin activity and increasing BDNF production may be therapeutic approaches for treating HD. |
Mendeley readers
The data shown below were compiled from readership statistics for 598 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 2% |
| United Kingdom | 5 | <1% |
| France | 4 | <1% |
| Germany | 2 | <1% |
| Canada | 2 | <1% |
| Austria | 1 | <1% |
| Italy | 1 | <1% |
| Portugal | 1 | <1% |
| Denmark | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 569 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 131 | 22% |
| Student > Bachelor | 88 | 15% |
| Student > Master | 84 | 14% |
| Researcher | 74 | 12% |
| Student > Postgraduate | 26 | 4% |
| Other | 92 | 15% |
| Unknown | 103 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 174 | 29% |
| Neuroscience | 109 | 18% |
| Biochemistry, Genetics and Molecular Biology | 88 | 15% |
| Medicine and Dentistry | 57 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 3% |
| Other | 36 | 6% |
| Unknown | 119 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2023.
All research outputs
#2,929,283
of 25,837,817 outputs
Outputs from Science
#33,481
of 83,358 outputs
Outputs of similar age
#2,692
of 43,283 outputs
Outputs of similar age from Science
#63
of 283 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,358 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.9. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 43,283 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 283 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.