Title |
Metabolomics and neuroanatomical evaluation of post-mortem changes in the hippocampus
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Published in |
Brain Structure and Function, March 2017
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DOI | 10.1007/s00429-017-1375-5 |
Pubmed ID | |
Authors |
Carolina Gonzalez-Riano, Silvia Tapia-González, Antonia García, Alberto Muñoz, Javier DeFelipe, Coral Barbas |
Abstract |
Understanding the human brain is the ultimate goal in neuroscience, but this is extremely challenging in part due to the fact that brain tissue obtained from autopsy is practically the only source of normal brain tissue and also since changes at different levels of biological organization (genetic, molecular, biochemical, anatomical) occur after death due to multiple mechanisms. Here we used metabolomic and anatomical techniques to study the possible relationship between post-mortem time (PT)-induced changes that may occur at both the metabolomics and anatomical levels in the same brains. Our experiments have mainly focused on the hippocampus of the mouse. We found significant metabolomic changes at 2 h PT, whereas the integrity of neurons and glia, at the anatomical/ neurochemical level, was not significantly altered during the first 5 h PT for the majority of histological markers. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 3 | 43% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 57% |
Scientists | 3 | 43% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 1% |
Unknown | 78 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 20% |
Student > Master | 10 | 13% |
Researcher | 10 | 13% |
Other | 4 | 5% |
Student > Doctoral Student | 3 | 4% |
Other | 15 | 19% |
Unknown | 21 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 12 | 15% |
Biochemistry, Genetics and Molecular Biology | 8 | 10% |
Agricultural and Biological Sciences | 8 | 10% |
Chemistry | 6 | 8% |
Medicine and Dentistry | 4 | 5% |
Other | 15 | 19% |
Unknown | 26 | 33% |