Title |
Stability and Change of Genetic and Environmental Effects on the Common Liability to Alcohol, Tobacco, and Cannabis DSM-IV Dependence Symptoms
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Published in |
Behavior Genetics, June 2013
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DOI | 10.1007/s10519-013-9599-5 |
Pubmed ID | |
Authors |
R. H. C. Palmer, S. E. Young, R. P. Corley, C. J. Hopfer, M. C. Stallings, J. K. Hewitt |
Abstract |
This study investigated the stability of genetic and environmental effects on the common liability to alcohol, tobacco, and cannabis dependence across adolescence and young adulthood. DSM-IV symptom counts from 2,361 adolescents were obtained using a structured diagnostic interview. Several sex-limited longitudinal common pathway models were used to examine gender differences in the magnitude of additive genetic (A), shared environment, and non-shared environmental effects over time. Model fitting indicated limited gender differences. Among older adolescents (i.e., age > 14), the heritability of the latent trait was estimated at 0.43 (0.05, 0.94) during the first wave and 0.63 (0.21, 0.83) during the second wave of assessment. A common genetic factor could account for genetic influences at both assessments, as well as the majority of the stability of SAV over time [rA = 1.00 (0.55, 1.00)]. These results suggest that early genetic factors continue to play a key role at later developmental stages. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Unknown | 45 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 15% |
Student > Doctoral Student | 6 | 13% |
Student > Bachelor | 5 | 11% |
Student > Ph. D. Student | 4 | 9% |
Student > Master | 4 | 9% |
Other | 7 | 15% |
Unknown | 13 | 28% |
Readers by discipline | Count | As % |
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Psychology | 12 | 26% |
Medicine and Dentistry | 7 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Mathematics | 1 | 2% |
Other | 5 | 11% |
Unknown | 17 | 37% |