Title |
Heterogeneity of fibrosis patterns in non‐alcoholic fatty liver disease supports the presence of multiple fibrogenic pathways
|
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Published in |
Liver International, January 2013
|
DOI | 10.1111/liv.12100 |
Pubmed ID | |
Authors |
Richard Skoien, Michelle M. Richardson, Julie R. Jonsson, Elizabeth E. Powell, Elizabeth M. Brunt, Brent A. Neuschwander‐Tetri, Prithi S. Bhathal, John B. Dixon, Paul E. O'Brien, Herbert Tilg, Alexander R. Moschen, Ulrich Baumann, Rachel M. Brown, Richard T. Couper, Nicholas D. Manton, Looi C. Ee, Martin Weltman, Andrew D. Clouston |
Abstract |
Adult non-alcoholic fatty liver disease (NAFLD) involves lobular necroinflammatory activity and fibrosis is typically centrilobular, whereas paediatric NAFLD has predominantly portal fibrosis. The reasons for these differences are unclear. We aimed to determine (a) how centrilobular and portal fibrosis in children relate to histological parameters; and (b) whether atypical fibrosis patterns exist in adults that are unexplained by current fibrogenesis models. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
Unknown | 59 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 15% |
Professor > Associate Professor | 8 | 13% |
Researcher | 7 | 12% |
Other | 5 | 8% |
Student > Bachelor | 4 | 7% |
Other | 15 | 25% |
Unknown | 12 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 32% |
Agricultural and Biological Sciences | 4 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Nursing and Health Professions | 2 | 3% |
Immunology and Microbiology | 2 | 3% |
Other | 11 | 18% |
Unknown | 20 | 33% |