| Title |
Multiple sclerosis is primarily a neurodegenerative disease
|
|---|---|
| Published in |
Journal of Neural Transmission, August 2013
|
| DOI | 10.1007/s00702-013-1080-3 |
| Pubmed ID | |
| Authors |
Abhijit Chaudhuri |
| Abstract |
The precise pathogenesis of multiple sclerosis is unknown. The assumption of a primary immunopathogenesis of the disease is seriously flawed and has failed to deliver an effective therapy for most patients. The progressive degeneration of grey and white matter is integral to the natural history of the disease and is reflected in the atrophy of brain and spinal cord. Demyelination is an essential component of this primary neurodegenerative process rather than the target of a systemic immune response. The primary pathology of multiple sclerosis is a process of neurodegeneration based on the integrity of the blood-brain barrier. Primary progressive multiple sclerosis is the prototype neurodegenerative disease, and the relapsing-remitting form in younger population represents the modifying effect of steroids (vitamin D, sex and stress hormones) on metabolic functions of the central nervous system. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 139 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 137 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 29 | 21% |
| Student > Master | 23 | 17% |
| Student > Ph. D. Student | 19 | 14% |
| Researcher | 11 | 8% |
| Student > Doctoral Student | 9 | 6% |
| Other | 23 | 17% |
| Unknown | 25 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 24% |
| Agricultural and Biological Sciences | 17 | 12% |
| Biochemistry, Genetics and Molecular Biology | 14 | 10% |
| Neuroscience | 14 | 10% |
| Nursing and Health Professions | 7 | 5% |
| Other | 22 | 16% |
| Unknown | 31 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2017.
All research outputs
#4,497,614
of 22,719,618 outputs
Outputs from Journal of Neural Transmission
#411
of 1,760 outputs
Outputs of similar age
#39,828
of 200,084 outputs
Outputs of similar age from Journal of Neural Transmission
#4
of 16 outputs
Altmetric has tracked 22,719,618 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,760 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 200,084 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.