| Title |
Epigenetics of eu- and heterochromatin in inverted and conventional nuclei from mouse retina
|
|---|---|
| Published in |
Chromosome Research, August 2013
|
| DOI | 10.1007/s10577-013-9375-7 |
| Pubmed ID | |
| Authors |
Anja Eberhart, Yana Feodorova, Congdi Song, Gerhard Wanner, Elena Kiseleva, Takahisa Furukawa, Hiroshi Kimura, Gunnar Schotta, Heinrich Leonhardt, Boris Joffe, Irina Solovei |
| Abstract |
To improve light propagation through the retina, the rod nuclei of nocturnal mammals are uniquely changed compared to the nuclei of other cells. In particular, the main classes of chromatin are segregated in them and form regular concentric shells in order; inverted in comparison to conventional nuclei. A broad study of the epigenetic landscape of the inverted and conventional mouse retinal nuclei indicated several differences between them and several features of general interest for the organization of the mammalian nuclei. In difference to nuclei with conventional architecture, the packing density of pericentromeric satellites and LINE-rich chromatin is similar in inverted rod nuclei; euchromatin has a lower packing density in both cases. A high global chromatin condensation in rod nuclei minimizes the structural difference between active and inactive X chromosome homologues. DNA methylation is observed primarily in the chromocenter, Dnmt1 is primarily associated with the euchromatic shell. Heterochromatin proteins HP1-alpha and HP1-beta localize in heterochromatic shells, whereas HP1-gamma is associated with euchromatin. For most of the 25 studied histone modifications, we observed predominant colocalization with a certain main chromatin class. Both inversions in rod nuclei and maintenance of peripheral heterochromatin in conventional nuclei are not affected by a loss or depletion of the major silencing core histone modifications in respective knock-out mice, but for different reasons. Maintenance of peripheral heterochromatin appears to be ensured by redundancy both at the level of enzymes setting the epigenetic code (writers) and the code itself, whereas inversion in rods rely on the absence of the peripheral heterochromatin tethers (absence of code readers). |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Luxembourg | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 102 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 31% |
| Researcher | 22 | 21% |
| Student > Master | 9 | 9% |
| Student > Doctoral Student | 7 | 7% |
| Student > Bachelor | 6 | 6% |
| Other | 15 | 14% |
| Unknown | 13 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 40 | 38% |
| Biochemistry, Genetics and Molecular Biology | 35 | 33% |
| Medicine and Dentistry | 6 | 6% |
| Neuroscience | 3 | 3% |
| Physics and Astronomy | 2 | 2% |
| Other | 5 | 5% |
| Unknown | 14 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2013.
All research outputs
#18,345,822
of 22,719,618 outputs
Outputs from Chromosome Research
#401
of 507 outputs
Outputs of similar age
#149,665
of 200,084 outputs
Outputs of similar age from Chromosome Research
#2
of 4 outputs
Altmetric has tracked 22,719,618 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 507 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 200,084 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.