| Chapter title |
Cerebral malaria: protection by erythropoietin.
|
|---|---|
| Chapter number | 19 |
| Book title |
Tissue-Protective Cytokines
|
| Published in |
Methods in molecular biology, March 2013
|
| DOI | 10.1007/978-1-62703-308-4_19 |
| Pubmed ID | |
| Book ISBNs |
978-1-62703-307-7, 978-1-62703-308-4
|
| Authors |
Bienvenu AL, Picot S, Anne-Lise Bienvenu, Stephane Picot, Bienvenu, Anne-Lise, Picot, Stephane |
| Abstract |
Cerebral malaria (CM) is still responsible for unacceptable death rate, while new antimalarial drugs were recently developed. CM pathophysiology shares essential biological features with cerebral ischemia. Because erythropoietin (Epo) was demonstrated to reduce mortality rate during experimental cerebral ischemia, in the early 2000, we wondered whether Epo could help to reduce the burden of CM. There is now evidence that Epo high doses could prevent early mortality during cerebral malaria. This evidence was obtained first using mice model of cerebral malaria, and later confirmed by prospective clinical trial in endemic area. High doses of Epo are needed to cross the blood-brain barrier and to favor the cytoprotective versus hematopoietic effect of this pleiotropic cytokine. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 14 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 21% |
| Student > Bachelor | 2 | 14% |
| Student > Master | 2 | 14% |
| Lecturer | 1 | 7% |
| Student > Ph. D. Student | 1 | 7% |
| Other | 3 | 21% |
| Unknown | 2 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 36% |
| Medicine and Dentistry | 3 | 21% |
| Immunology and Microbiology | 1 | 7% |
| Computer Science | 1 | 7% |
| Neuroscience | 1 | 7% |
| Other | 1 | 7% |
| Unknown | 2 | 14% |