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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Epigenetic Regulation of Mouse Sex Determination by the Histone Demethylase Jmjd1a
|
|---|---|
| Published in |
Science, September 2013
|
| DOI | 10.1126/science.1239864 |
| Pubmed ID | |
| Authors |
Shunsuke Kuroki, Shogo Matoba, Mika Akiyoshi, Yasuko Matsumura, Hitoshi Miyachi, Nathan Mise, Kuniya Abe, Atsuo Ogura, Dagmar Wilhelm, Peter Koopman, Masami Nozaki, Yoshiakira Kanai, Yoichi Shinkai, Makoto Tachibana |
| Abstract |
Developmental gene expression is defined through cross-talk between the function of transcription factors and epigenetic status, including histone modification. Although several transcription factors play crucial roles in mammalian sex determination, how epigenetic regulation contributes to this process remains unknown. We observed male-to-female sex reversal in mice lacking the H3K9 demethylase Jmjd1a and found that Jmjd1a regulates expression of the mammalian Y chromosome sex-determining gene Sry. Jmjd1a directly and positively controls Sry expression by regulating H3K9me2 marks. These studies reveal a pivotal role of histone demethylation in mammalian sex determination. |
X Demographics
The data shown below were collected from the profiles of 67 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 11 | 16% |
| United States | 8 | 12% |
| United Kingdom | 5 | 7% |
| Netherlands | 2 | 3% |
| Australia | 2 | 3% |
| France | 2 | 3% |
| Spain | 2 | 3% |
| Russia | 1 | 1% |
| Canada | 1 | 1% |
| Other | 5 | 7% |
| Unknown | 28 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 54 | 81% |
| Scientists | 10 | 15% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
| Practitioners (doctors, other healthcare professionals) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 280 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 4 | 1% |
| Netherlands | 2 | <1% |
| United States | 2 | <1% |
| United Kingdom | 1 | <1% |
| Singapore | 1 | <1% |
| Norway | 1 | <1% |
| Denmark | 1 | <1% |
| France | 1 | <1% |
| China | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 265 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 68 | 24% |
| Student > Ph. D. Student | 53 | 19% |
| Student > Master | 24 | 9% |
| Student > Bachelor | 22 | 8% |
| Student > Doctoral Student | 18 | 6% |
| Other | 58 | 21% |
| Unknown | 37 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 123 | 44% |
| Biochemistry, Genetics and Molecular Biology | 68 | 24% |
| Medicine and Dentistry | 19 | 7% |
| Chemistry | 6 | 2% |
| Immunology and Microbiology | 4 | 1% |
| Other | 15 | 5% |
| Unknown | 45 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 128. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2017.
All research outputs
#324,685
of 25,399,318 outputs
Outputs from Science
#8,685
of 82,955 outputs
Outputs of similar age
#2,349
of 209,267 outputs
Outputs of similar age from Science
#92
of 870 outputs
Altmetric has tracked 25,399,318 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 82,955 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.7. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,267 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 870 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.