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X Demographics
Mendeley readers
Attention Score in Context
| Title |
m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells
|
|---|---|
| Published in |
Cell Reports, March 2017
|
| DOI | 10.1016/j.celrep.2017.02.059 |
| Pubmed ID | |
| Authors |
Qi Cui, Hailing Shi, Peng Ye, Li Li, Qiuhao Qu, Guoqiang Sun, Guihua Sun, Zhike Lu, Yue Huang, Cai-Guang Yang, Arthur D. Riggs, Chuan He, Yanhong Shi |
| Abstract |
RNA modifications play critical roles in important biological processes. However, the functions of N(6)-methyladenosine (m(6)A) mRNA modification in cancer biology and cancer stem cells remain largely unknown. Here, we show that m(6)A mRNA modification is critical for glioblastoma stem cell (GSC) self-renewal and tumorigenesis. Knockdown of METTL3 or METTL14, key components of the RNA methyltransferase complex, dramatically promotes human GSC growth, self-renewal, and tumorigenesis. In contrast, overexpression of METTL3 or inhibition of the RNA demethylase FTO suppresses GSC growth and self-renewal. Moreover, inhibition of FTO suppresses tumor progression and prolongs lifespan of GSC-grafted mice substantially. m(6)A sequencing reveals that knockdown of METTL3 or METTL14 induced changes in mRNA m(6)A enrichment and altered mRNA expression of genes (e.g., ADAM19) with critical biological functions in GSCs. In summary, this study identifies the m(6)A mRNA methylation machinery as promising therapeutic targets for glioblastoma. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 20% |
| Australia | 1 | 7% |
| Germany | 1 | 7% |
| Peru | 1 | 7% |
| Norway | 1 | 7% |
| Taiwan | 1 | 7% |
| Turkey | 1 | 7% |
| United Kingdom | 1 | 7% |
| Unknown | 5 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 53% |
| Scientists | 3 | 20% |
| Science communicators (journalists, bloggers, editors) | 2 | 13% |
| Practitioners (doctors, other healthcare professionals) | 2 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 543 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 540 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 130 | 24% |
| Student > Bachelor | 72 | 13% |
| Researcher | 60 | 11% |
| Student > Master | 52 | 10% |
| Student > Doctoral Student | 32 | 6% |
| Other | 53 | 10% |
| Unknown | 144 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 210 | 39% |
| Agricultural and Biological Sciences | 75 | 14% |
| Medicine and Dentistry | 39 | 7% |
| Neuroscience | 18 | 3% |
| Chemistry | 10 | 2% |
| Other | 37 | 7% |
| Unknown | 154 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2024.
All research outputs
#1,250,655
of 25,382,440 outputs
Outputs from Cell Reports
#2,874
of 12,965 outputs
Outputs of similar age
#24,985
of 324,443 outputs
Outputs of similar age from Cell Reports
#54
of 241 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,965 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.3. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,443 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 241 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.