| Title |
Human predisposition to cognitive impairment and its relation with environmental exposure to potentially toxic elements
|
|---|---|
| Published in |
Environmental Geochemistry and Health, March 2017
|
| DOI | 10.1007/s10653-017-9928-3 |
| Pubmed ID | |
| Authors |
Marina M. S. Cabral Pinto, A. Paula Marinho-Reis, Agostinho Almeida, Carlos M. Ordens, Maria M. V. G. Silva, Sandra Freitas, Mário R. Simões, Paula I. Moreira, Pedro A. Dinis, M. Luísa Diniz, Eduardo A. Ferreira da Silva, M. Teresa Condesso de Melo |
| Abstract |
New lines of evidence suggest that less than 10% of neurodegenerative diseases have a strict genetic aetiology and other factors may be prevalent. Environmental exposures to potentially toxic elements appear to be a risk factor for Parkinson's, Alzheimer's and sclerosis diseases. This study proposes a multidisciplinary approach combining neurosciences, psychology and environmental sciences while integrating socio-economic, neuropsychological, environmental and health data. We present the preliminary results of a neuropsychological assessment carried out in elderly residents of the industrial city of Estarreja. A battery of cognitive tests and a personal questionnaire were administered to the participants. Multivariate analysis and multiple linear regression analysis were used to identify potential relationships between the cognitive status of the participants and environmental exposure to potentially toxic elements. The results suggest a relationship between urinary PTEs levels and the incidence of cognitive disorders. They also point towards water consumption habits and profession as relevant factors of exposure. Linear regression models show that aluminium (R (2) = 38%), cadmium (R (2) = 11%) and zinc (R (2) = 6%) are good predictors of the scores of the Mini-Mental State Examination cognitive test. Median contents (µg/l) in groundwater are above admissible levels for drinking water for aluminium (371), iron (860), manganese (250), and zinc (305). While the World Health Organization does not provide health-based reference values for aluminium, results obtained from this study suggest that it may have an important role in the cognitive status of the elderly. Urine proved to be a suitable biomarker of exposure both to elements with low and high excretion rates. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 45% |
| Unknown | 6 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 96 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 13% |
| Researcher | 8 | 8% |
| Student > Ph. D. Student | 7 | 7% |
| Professor | 6 | 6% |
| Student > Bachelor | 6 | 6% |
| Other | 19 | 20% |
| Unknown | 38 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Medicine and Dentistry | 6 | 6% |
| Social Sciences | 6 | 6% |
| Earth and Planetary Sciences | 5 | 5% |
| Neuroscience | 5 | 5% |
| Other | 21 | 22% |
| Unknown | 47 | 49% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2018.
All research outputs
#5,792,105
of 23,854,458 outputs
Outputs from Environmental Geochemistry and Health
#127
of 856 outputs
Outputs of similar age
#89,318
of 310,512 outputs
Outputs of similar age from Environmental Geochemistry and Health
#4
of 14 outputs
Altmetric has tracked 23,854,458 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 856 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,512 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.