| Title |
A growing role for the Hippo signaling pathway in the heart
|
|---|---|
| Published in |
Journal of Molecular Medicine, March 2017
|
| DOI | 10.1007/s00109-017-1525-5 |
| Pubmed ID | |
| Authors |
Yu Zhang, Dominic P. Del Re |
| Abstract |
Heart disease is a major cause of clinical morbidity and mortality, and a significant health and economic burden worldwide. The loss of functional cardiomyocytes, often a result of myocardial infarction, leads to impaired cardiac output and ultimately heart failure. Therefore, efforts to improve cardiomyocyte viability and stimulate cardiomyocyte proliferation remain attractive therapeutic goals. Originally identified in Drosophila, the Hippo signaling pathway is highly conserved from flies to humans and regulates organ size through modulation of both cell survival and proliferation. This is particularly relevant to the heart, an organ with limited regenerative ability. Recent work has demonstrated a critical role for this signaling cascade in determining heart development, homeostasis, injury and the potential for regeneration. Here we review the function of canonical and non-canonical Hippo signaling in cardiomyocytes, with a particular focus on proliferation and survival, and how this impacts the stressed adult heart. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 44 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 18% |
| Student > Ph. D. Student | 6 | 14% |
| Researcher | 4 | 9% |
| Other | 3 | 7% |
| Student > Postgraduate | 3 | 7% |
| Other | 4 | 9% |
| Unknown | 16 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 23% |
| Agricultural and Biological Sciences | 6 | 14% |
| Medicine and Dentistry | 6 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Economics, Econometrics and Finance | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 17 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2023.
All research outputs
#7,022,334
of 25,365,817 outputs
Outputs from Journal of Molecular Medicine
#456
of 1,640 outputs
Outputs of similar age
#103,292
of 314,411 outputs
Outputs of similar age from Journal of Molecular Medicine
#2
of 9 outputs
Altmetric has tracked 25,365,817 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1,640 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 71% of its peers.
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We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.