| Title |
14-3-3s are potential biomarkers for HIV-related neurodegeneration
|
|---|---|
| Published in |
Journal of NeuroVirology, July 2012
|
| DOI | 10.1007/s13365-012-0121-2 |
| Pubmed ID | |
| Authors |
Diana Morales, Efthimios C. M. Skoulakis, Summer F. Acevedo |
| Abstract |
Over the last decade, it has become evident that 14-3-3 proteins are essential for primary cell functions. These proteins are abundant throughout the body, including the central nervous system and interact with other proteins in both cell cycle and apoptotic pathways. Examination of cerebral spinal fluid in humans suggests that 14-3-3s including 14-3-3ε (YWHAE) are up-regulated in several neurological diseases, and loss or duplication of the YWHAE gene leads to Miller-Dieker syndrome. The goal of this review is to examine the utility of 14-3-3s as a marker of human immune deficiency virus (HIV)-dependent neurodegeneration and also as a tool to track disease progression. To that end, we describe mechanisms implicating 14-3-3s in neurological diseases and summarize evidence of its interactions with HIV accessory and co-receptor proteins. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Unknown | 49 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 24% |
| Student > Master | 9 | 18% |
| Researcher | 7 | 14% |
| Student > Bachelor | 5 | 10% |
| Professor | 2 | 4% |
| Other | 4 | 8% |
| Unknown | 11 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 22% |
| Biochemistry, Genetics and Molecular Biology | 8 | 16% |
| Medicine and Dentistry | 7 | 14% |
| Psychology | 3 | 6% |
| Neuroscience | 3 | 6% |
| Other | 6 | 12% |
| Unknown | 12 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2013.
All research outputs
#18,347,414
of 22,721,584 outputs
Outputs from Journal of NeuroVirology
#653
of 925 outputs
Outputs of similar age
#125,803
of 163,988 outputs
Outputs of similar age from Journal of NeuroVirology
#3
of 3 outputs
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