| Title |
Estrogen, astrocytes and the neuroendocrine control of metabolism
|
|---|---|
| Published in |
Reviews in Endocrine and Metabolic Disorders, September 2013
|
| DOI | 10.1007/s11154-013-9263-7 |
| Pubmed ID | |
| Authors |
E. Fuente-Martin, C. Garcia-Caceres, E. Morselli, D. J. Clegg, J. A. Chowen, B. Finan, R. D. Brinton, M. H. Tschöp |
| Abstract |
Obesity, and its associated comorbidities such as type 2 diabetes, cardiovascular diseases, and certain cancers, represent major health challenges. Importantly, there is a sexual dimorphism with respect to the prevalence of obesity and its associated metabolic diseases, implicating a role for gonadal hormones. Specifically, estrogens have been demonstrated to regulate metabolism perhaps by acting as a leptin mimetic in the central nervous system (CNS). CNS estrogen receptors (ERs) include ER alpha (ERα) and ER beta (ERβ), which are found in nuclear, cytoplasmic and membrane sites throughout the brain. Additionally, estrogens can bind to and activate a G protein-coupled estrogen receptor (GPER), which is a membrane-associated ER. ERs are expressed on neurons as well as glia, which are known to play a major role in providing nutrient supply for neurons and have recently received increasing attention for their potentially important involvement in the CNS regulation of systemic metabolism and energy balance. This brief overview summarizes data focusing on the potential role of astrocytic estrogen action as a key component of estrogenic modulation responsible for mediating the sexual dimorphism in body weight regulation and obesity. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 139 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 136 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 18% |
| Researcher | 23 | 17% |
| Student > Master | 21 | 15% |
| Student > Bachelor | 17 | 12% |
| Professor > Associate Professor | 9 | 6% |
| Other | 21 | 15% |
| Unknown | 23 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 24% |
| Neuroscience | 32 | 23% |
| Medicine and Dentistry | 18 | 13% |
| Biochemistry, Genetics and Molecular Biology | 14 | 10% |
| Sports and Recreations | 4 | 3% |
| Other | 10 | 7% |
| Unknown | 28 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2013.
All research outputs
#19,440,618
of 23,911,072 outputs
Outputs from Reviews in Endocrine and Metabolic Disorders
#420
of 505 outputs
Outputs of similar age
#150,547
of 200,748 outputs
Outputs of similar age from Reviews in Endocrine and Metabolic Disorders
#11
of 14 outputs
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