| Title |
Therapeutic Effect of Transplanted Human Wharton’s Jelly Stem Cell-Derived Oligodendrocyte Progenitor Cells (hWJ-MSC-derived OPCs) in an Animal Model of Multiple Sclerosis
|
|---|---|
| Published in |
Molecular Neurobiology, August 2013
|
| DOI | 10.1007/s12035-013-8543-2 |
| Pubmed ID | |
| Authors |
Elmira Mikaeili Agah, Kazem Parivar, Mohammad Taghi Joghataei |
| Abstract |
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). A potential new therapeutic approach for MS is cell transplantation which may promote remyelination. We transplanted human Wharton's jelly stem cell-derived oligodendrocyte progenitor cells (hWJ-MSC-derived OPCs) into the brain ventricles of mice induced with experimental autoimmune encephalomyelitis (EAE), the animal model of MS. We studied the effect of the transplanted OPCs on the functional and pathological manifestations of the disease. Transplanted hWJ-MSC-derived OPCs significantly reduced the clinical signs of EAE. Histological examinations showed that remyelination was significantly increased after transplantation. These results suggest that hWJ-MSC-derived OPCs promote the regeneration of myelin sheaths in the brain. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | 2% |
| Unknown | 58 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 14% |
| Student > Master | 6 | 10% |
| Student > Bachelor | 6 | 10% |
| Researcher | 5 | 8% |
| Student > Doctoral Student | 4 | 7% |
| Other | 14 | 24% |
| Unknown | 16 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 17% |
| Agricultural and Biological Sciences | 9 | 15% |
| Biochemistry, Genetics and Molecular Biology | 5 | 8% |
| Neuroscience | 5 | 8% |
| Veterinary Science and Veterinary Medicine | 3 | 5% |
| Other | 8 | 14% |
| Unknown | 19 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2013.
All research outputs
#18,347,414
of 22,721,584 outputs
Outputs from Molecular Neurobiology
#2,451
of 3,434 outputs
Outputs of similar age
#149,475
of 200,084 outputs
Outputs of similar age from Molecular Neurobiology
#19
of 30 outputs
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