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Mendeley readers
Attention Score in Context
| Title |
Functional neuroanatomical associations of working memory in early‐onset Alzheimer's disease
|
|---|---|
| Published in |
International Journal of Geriatric Psychiatry, March 2017
|
| DOI | 10.1002/gps.4703 |
| Pubmed ID | |
| Authors |
Christopher Kobylecki, Cathleen Haense, Jennifer M. Harris, Cheryl L. Stopford, Shailendra H. Segobin, Matthew Jones, Anna M.T. Richardson, Alexander Gerhard, José Anton‐Rodriguez, Jennifer C. Thompson, Karl Herholz, Julie S. Snowden |
| Abstract |
To characterize metabolic correlates of working memory impairment in clinically defined subtypes of early-onset Alzheimer's disease. Established models of working memory suggest a key role for frontal lobe function, yet the association in Alzheimer's disease between working memory impairment and visuospatial and language symptoms suggests that temporoparietal neocortical dysfunction may be responsible. Twenty-four patients with predominantly early-onset Alzheimer's disease were clinically classified into groups with predominantly amnestic, multidomain or visual deficits. Patients underwent neuropsychological evaluation focused on the domains of episodic and working memory, T1-weighted magnetic resonance imaging and brain fluorodeoxyglucose positron emission tomography. Fluorodeoxyglucose positron emission tomography data were analysed by using a region-of-interest approach. Patients with multidomain and visual presentations performed more poorly on tests of working memory compared with amnestic Alzheimer's disease. Working memory performance correlated with glucose metabolism in left-sided temporoparietal, but not frontal neocortex. Carriers of the apolipoprotein E4 gene showed poorer episodic memory and better working memory performance compared with noncarriers. Our findings support the hypothesis that working memory changes in early-onset Alzheimer's disease are related to temporoparietal rather than frontal hypometabolism and show dissociation from episodic memory performance. They further support the concept of subtypes of Alzheimer's disease with distinct cognitive profiles due to prominent neocortical dysfunction early in the disease course. Copyright © 2017 John Wiley & Sons, Ltd. |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 65 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 12 | 18% |
| Student > Master | 11 | 17% |
| Researcher | 6 | 9% |
| Student > Ph. D. Student | 6 | 9% |
| Professor | 2 | 3% |
| Other | 8 | 12% |
| Unknown | 20 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 13 | 20% |
| Neuroscience | 12 | 18% |
| Medicine and Dentistry | 7 | 11% |
| Biochemistry, Genetics and Molecular Biology | 3 | 5% |
| Nursing and Health Professions | 3 | 5% |
| Other | 5 | 8% |
| Unknown | 22 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2017.
All research outputs
#4,602,440
of 24,458,924 outputs
Outputs from International Journal of Geriatric Psychiatry
#757
of 2,527 outputs
Outputs of similar age
#77,397
of 312,695 outputs
Outputs of similar age from International Journal of Geriatric Psychiatry
#18
of 45 outputs
Altmetric has tracked 24,458,924 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,527 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,695 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.