| Title |
Levodopa reverses gait asymmetries related to anhedonia and magical ideation
|
|---|---|
| Published in |
European Archives of Psychiatry and Clinical Neuroscience, November 2004
|
| DOI | 10.1007/s00406-004-0531-0 |
| Pubmed ID | |
| Authors |
C. Mohr, T. Landis, H. S. Bracha, M. Fathi, P. Brugger |
| Abstract |
Animals and men turn preferentially away from the hemisphere with the more active dopamine (DA) system. Consistent with the idea of a right-hemispheric hyperdopaminergia in schizophrenia, a leftsided turning bias was described for unmedicated psychotic patients. We investigated the modulating role of DA and schizophrenia-like thought on whole-body turns in a controlled double-blind study. The number of veers to either side when walking blindfolded straight ahead (20 meter) was assessed in 40 healthy righthanded men (20 men received levodopa, the remaining participants placebo). Side preferences were analyzed in terms of individuals' positive (Magical Ideation, MI) and negative (Physical Anhedonia, PhysAn) schizotypal features. In the placebo group, increasing MI scores were related to increasing left-sided veering and increasing PhysAn scores were related to increasing right-sided veering. In the levodopa group, this relationship between preferred veering side and type of schizotypy was reversed. The finding in the placebo group suggests an association between MI and a relative right-hemispheric hyperdopaminergia. Unexpectedly, levodopa did not enhance this veering bias, but reversed it, suggesting that psychosis-protective mechanisms exist in the healthy positive "schizotypic" brain. Also unexpectedly, levodopa made "anhedonics" veer like "magics" after placebo, suggesting that DA agonists suppress negative schizotypal symptoms. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 51 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 17% |
| Student > Master | 8 | 15% |
| Student > Ph. D. Student | 7 | 13% |
| Professor > Associate Professor | 5 | 10% |
| Student > Bachelor | 4 | 8% |
| Other | 11 | 21% |
| Unknown | 8 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 18 | 35% |
| Medicine and Dentistry | 6 | 12% |
| Neuroscience | 5 | 10% |
| Agricultural and Biological Sciences | 3 | 6% |
| Social Sciences | 3 | 6% |
| Other | 6 | 12% |
| Unknown | 11 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2013.
All research outputs
#15,378,098
of 23,815,455 outputs
Outputs from European Archives of Psychiatry and Clinical Neuroscience
#871
of 1,243 outputs
Outputs of similar age
#52,586
of 59,231 outputs
Outputs of similar age from European Archives of Psychiatry and Clinical Neuroscience
#15
of 18 outputs
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So far Altmetric has tracked 1,243 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
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