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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420
|
|---|---|
| Published in |
Science, March 2017
|
| DOI | 10.1126/science.aag1006 |
| Pubmed ID | |
| Authors |
Nicolas Blondiaux, Martin Moune, Matthieu Desroses, Rosangela Frita, Marion Flipo, Vanessa Mathys, Karine Soetaert, Mehdi Kiass, Vincent Delorme, Kamel Djaout, Vincent Trebosc, Christian Kemmer, René Wintjens, Alexandre Wohlkönig, Rudy Antoine, Ludovic Huot, David Hot, Mireia Coscolla, Julia Feldmann, Sebastien Gagneux, Camille Locht, Priscille Brodin, Marc Gitzinger, Benoit Déprez, Nicolas Willand, Alain R Baulard |
| Abstract |
Antibiotic resistance is one of the biggest threats to human health globally. Alarmingly, multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis have now spread worldwide. Some key antituberculosis antibiotics are prodrugs, for which resistance mechanisms are mainly driven by mutations in the bacterial enzymatic pathway required for their bioactivation. We have developed drug-like molecules that activate a cryptic alternative bioactivation pathway of ethionamide in M. tuberculosis, circumventing the classic activation pathway in which resistance mutations have now been observed. The first-of-its-kind molecule, named SMARt-420 (Small Molecule Aborting Resistance), not only fully reverses ethionamide-acquired resistance and clears ethionamide-resistant infection in mice, it also increases the basal sensitivity of bacteria to ethionamide. |
X Demographics
The data shown below were collected from the profiles of 87 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 13 | 15% |
| United Kingdom | 12 | 14% |
| United States | 5 | 6% |
| Netherlands | 3 | 3% |
| India | 2 | 2% |
| South Africa | 2 | 2% |
| Spain | 2 | 2% |
| Ireland | 2 | 2% |
| Belgium | 1 | 1% |
| Other | 10 | 11% |
| Unknown | 35 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 51 | 59% |
| Scientists | 29 | 33% |
| Practitioners (doctors, other healthcare professionals) | 5 | 6% |
| Science communicators (journalists, bloggers, editors) | 2 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 246 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| France | 1 | <1% |
| Hungary | 1 | <1% |
| Finland | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 239 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 54 | 22% |
| Researcher | 47 | 19% |
| Student > Master | 26 | 11% |
| Student > Bachelor | 24 | 10% |
| Student > Postgraduate | 13 | 5% |
| Other | 39 | 16% |
| Unknown | 43 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 63 | 26% |
| Agricultural and Biological Sciences | 43 | 17% |
| Chemistry | 31 | 13% |
| Immunology and Microbiology | 24 | 10% |
| Medicine and Dentistry | 8 | 3% |
| Other | 21 | 9% |
| Unknown | 56 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 140. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2022.
All research outputs
#296,206
of 25,382,440 outputs
Outputs from Science
#8,037
of 82,915 outputs
Outputs of similar age
#6,319
of 322,508 outputs
Outputs of similar age from Science
#162
of 1,239 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 82,915 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.7. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,508 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 1,239 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.