↓ Skip to main content

Derived variants at six genes explain nearly half of size reduction in dog breeds

Overview of attention for article published in Genome Research, September 2013
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

news
1 news outlet
blogs
2 blogs
twitter
23 X users
facebook
3 Facebook pages
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
129 Dimensions

Readers on

mendeley
190 Mendeley
citeulike
1 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Derived variants at six genes explain nearly half of size reduction in dog breeds
Published in
Genome Research, September 2013
DOI 10.1101/gr.157339.113
Pubmed ID
Authors

Maud Rimbault, Holly C. Beale, Jeffrey J. Schoenebeck, Barbara C. Hoopes, Jeremy J. Allen, Paul Kilroy-Glynn, Robert K. Wayne, Nathan B. Sutter, Elaine A. Ostrander

Abstract

Selective breeding of dogs by humans has generated extraordinary diversity in body size. A number of multibreed analyses have been undertaken to identify the genetic basis of this diversity. We analyzed four loci discovered in a previous genome-wide association study that used 60,968 SNPs to identify size-associated genomic intervals, which were too large to assign causative roles to genes. First, we performed fine-mapping to define critical intervals that included the candidate genes GHR, HMGA2, SMAD2, and STC2, identifying five highly associated markers at the four loci. We hypothesize that three of the variants are likely to be causative. We then genotyped each marker, together with previously reported size-associated variants in the IGF1 and IGF1R genes, on a panel of 500 domestic dogs from 93 breeds, and identified the ancestral allele by genotyping the same markers on 30 wild canids. We observed that the derived alleles at all markers correlated with reduced body size, and smaller dogs are more likely to carry derived alleles at multiple markers. However, breeds are not generally fixed at all markers; multiple combinations of genotypes are found within most breeds. Finally, we show that 46%-52.5% of the variance in body size of dog breeds can be explained by seven markers in proximity to exceptional candidate genes. Among breeds with standard weights <41 kg (90 lb), the genotypes accounted for 64.3% of variance in weight. This work advances our understanding of mammalian growth by describing genetic contributions to canine size determination in non-giant dog breeds.

X Demographics

X Demographics

The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 190 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 7 4%
Germany 1 <1%
Korea, Republic of 1 <1%
Hungary 1 <1%
Finland 1 <1%
Brazil 1 <1%
Argentina 1 <1%
New Zealand 1 <1%
Unknown 176 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 38 20%
Researcher 38 20%
Student > Bachelor 31 16%
Student > Master 12 6%
Other 10 5%
Other 31 16%
Unknown 30 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 70 37%
Biochemistry, Genetics and Molecular Biology 43 23%
Veterinary Science and Veterinary Medicine 15 8%
Medicine and Dentistry 6 3%
Social Sciences 5 3%
Other 20 11%
Unknown 31 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 41. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2022.
All research outputs
#1,003,754
of 25,405,598 outputs
Outputs from Genome Research
#366
of 4,429 outputs
Outputs of similar age
#8,625
of 210,863 outputs
Outputs of similar age from Genome Research
#6
of 44 outputs
Altmetric has tracked 25,405,598 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,429 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.3. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,863 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.